eprintid: 21974
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/19/74
datestamp: 2023-04-02 10:47:18
lastmod: 2023-04-02 10:47:18
status_changed: 2023-04-02 10:47:18
type: thesis
metadata_visibility: show
creators_name: Angraini, Ega Deski
creators_name: Siska, Siska
creators_name: Hanani, Endang
title: REVIEW ARTIKEL: SKRINING FITOKIMIA DAN UJI AKTIVITAS
ANTIHIPERTENSI ROSELA (HIBISCUS SABDARIFFA L.)
TERHADAP PENURUNAN TEKANAN DARAH
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Hipertensi merupakan salah satu masalah penyakit pada kesehatan masyarakat
yang utama di negara maju dan berkembang. Hipertensi adalah tekanan darah
tinggi sistolik lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90
mmHg dapat menyebabkan berbagai komplikasi kesehatan yang membahayakan
nyawa bila dibiarkan dan dapat menyebabkan peningkatan risiko terjadinya
penyakit jantung, stroke, hingga kematian. Tujuan dari penelitian ini yaitu untuk
mengumpulkan informasi mengenai perkembangan tanaman rosela (Hibiscus
sabdariffa L.) dengan kandungan senyawa kimia dan uji aktivitas sebagai
antihipertensi, bila ditinjau dari Narrative Review hasil dari jurnal yang ditemukan
dapat disimpulkan bahwa (Hibiscus sabdariffa L.) memiliki kandungan senyawa
kimia yang terkandung yaitu alkaloid, flavonoid, saponin, tanin, terpenoid,
triterpenoid, glikosida, glikosida jantung, karbohidrat, fenolik, sterol, hidroquinon.
Hasil Narrative Review uji aktivitas antihipertensi rosela (Hibiscus sabdariffa L.)
efektif menurunkan hipertensi dengan mekanisme pra klinik dan klinik.
Kata kunci: (Hibiscus sabdariffa L.), screnning, anthyhipertension.
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
referencetext: Abubakar M, U. A. M. U. (2015). Antihypertensive activity of Hibiscus Sabdariffa
aqueous calyx extract in Albino rats. Sky Journal of Biochemistry Research,
4(3), 16–020. http://www.skyjournals.org/SJBR
Ahad, A., Raish, M., bin Jardan, Y. A., Alam, M. A., Al-Mohizea, A. M., & AlJenoobi, F. I. (2020). Effect of Hibiscus sabdariffa and Zingiber officinale on
the antihypertensive activity and pharmacokinetic of losartan in hypertensive
rats. Xenobiotica, 50(7), 847–857.
Ambari, Y., Fitri, S., & Nurrosyidah, I. H. (2021). Uji Aktivitas Antioksidan
Masker Gel Peel-off Ekstrak Etanol Kelopak Bunga Rosela (Hibiscus
sabdariffa L.) dengan Metode DPPH (1,1-Diphenyl-2-picryhydrazyl)
Antioxidant Activity Test of Peel-off Mask Containing Roselle Calices
Ethanol Extract using DPPH (1,1-Diphenyl-2-picryhydrazyl) Method. In
Pharmaceutical Journal of Indonesia (Vol. 18, Issue 01).
Ari, M., Alu, S., Longtep, B., Alum, I., Usman, A., Kwassau, S., & Onu, J.
(2015). Nutrient Composition and Phytochemical Screening of Crushed,
Toasted and Fermented Roselle (Hibiscus sabdariffa L) Seeds. Annual
Research & Review in Biology, 7(1), 39–44.
Arvind Mungole, A. C. (2011). Hibiscus Sabdariffa L A Rich Source Of
Secondary Metabolites. Volume 6, Issue 1, January–February 2011; Article018ISSN 0976 –044XInternational Journal of Pharmaceutical Sciences
Review and Research, 6(1), 83–87.
Ayu, G., Lestari, D., Cahyadi, K. D., Ketut Esati, N., & Suprihatin, I. E. (2022).
Skrining Fitokimia Dan Uji Aktivitas Antioksidan Ekstrak Etanol Bunga
Rosella Ungu (Hibiscus Sabdariffa L.). Jamb.J.Chem, 4(1), 17–24.
BPOM RI. (2010). Serial Data Ilmiah Terkini Tumbuhan Obat: Rosella
(Hibiscuss sabdariffa L.). Direktorat Obat Asli Indonesia. BPOM RI. Hlm 2
Brahma, J., Singh, B., & Rethy, P. (2014). Bioactive and Nutraceutical
Coumpound Manipulation In Hibiscus Sabdariffa L. Leaves: A Common
Undershrub Consumed By The Bodo Tribes Of BTC, Assam, India.
International research journal L of pharmacy, 5(6), 463–467.
Dahlia, A. A., Amin, A., & Lestari, R. (2012). Identifikasi Morfologi dan
Parameter Spesifik Simplisia dan Ekstrak Daun Rosella (Hibiscus sabdariffa
L.) asal Kab. Enrekang (Sulawesi Selatan). As-Syifaa, 04(02), 159–175.
Elkafrawy, N., Younes, K., Naguib, A., Badr, H., Kamal Zewain, S., Kamel, M.,
Raoof, G. F. A., M. El-Desoky, A., & Mohamed, S. (2020). Antihypertensive
efficacy and safety of a standardized herbal medicinal product of Hibiscus
sabdariffa and Olea europaea extracts (NW Roselle): A phase-II,
randomized, double-blind, captopril-controlled clinical trial. Phytotherapy
Research, 34(12), 3379–3387.
Eltayeib, A. A., & Hamade, H. (2014). Phytochemical and Chemical Composition
of Water Extract of Hibiscus Sabdariffa (Red Karkade Calyces) in North
Kordofan State-Sudan. International Journal of Advanced Research in
Chemical Science (IJARCS), 1(6), 10–13.
Eyitayo Balogun, M., Nwachukwu, D., & Besong, E. E. (2016). Antihypertensive
effect of methanolic extract from the leaves of Hibiscus Sabdariffa L. in rats.
Fitriaturosidah, I., Kusnadi, J., Nurnasari, E., Nurindah, & Hariyono, B.(2022).
Phytochemical screening and chemical compound of green roselle (Hibiscus
sabdariffa L.) and potential antibacterial activities. IOP Conference Series:
Earth and Environmental Science, 974(1).
Garbi, M. I., Saleh, M. S., Badri, A. M., Ibrahim, I. T., Mohammed, S. F.,
Alhassan, M. S., Elshikh, A. A., & Kabbashi, A. S. (n.d.). Antibacterial
activity, phytochemical screening and cytotoxicity of Hibiscus sabdariffa
(calyx).
Grajeda-Iglesias, C., Figueroa-Espinoza, M. C., Barouh, N., Baréa, B., Fernandes,
A., de Freitas, V., & Salas, E. (2016). Isolation and Characterization of
Anthocyanins from Hibiscus sabdariffa Flowers. Journal of Natural
Products, 79(7), 1709–1718.
Hagr, T. E., & Adam, I. A. (2020). Phytochemical Analysis, Antibacterial and
antioxidant Activities of Essential Oil from Hibiscus sabdariffa (L) Seeds,
(Sudanese Karkadi). Progress in Chemical and Biochemical Research
Journal Homepage: Progress in Chemical and Biochemical Research,
2020(3), 194–201.
Hanani, E. (2021). Buku Ajar Farmakognosi. UPT UHAMKA Press. Hlm: 180-
181
Hanani, E. (2021). Analisis fitokimia. ECG: Jakarta. Hlm: 11,14,15
Harmili, H., Fadlilah, S., & Sucipto, A. (2021). Effectiveness Of Hibiscus
sabdariffa On Blood Pressure Of Hypertension Patients. Jurnal Keperawatan
Respati Yogyakarta, 8(2), 99–102.
Ismail, S., Hayati, N., & Rahmawati, N. (2018). Mechanism of action vasodilation
Annona muricata L. leaves extract mediated vascular smooth muscles. IOP
Conference Series: Earth and Environmental Science, 144(1). 
Katzung, B. G. (2015) Basic and Clinical Pharmacology. Hlm: 173
Kementrian kesehatan RI. Pedoman Teknis penemuan dan Tatalaksana
Hipertensi, Kementrian kesehatan RI. Jakarta,2013. Hlm: 5.
Mardiah, Rungkat Zakaria, F., Prangdimurti, E., & Damanik, R. (2015). Changes
In Chemical Content Of Red And Purple Roselle (Hibiscus sabdariffa L.)
Extractdried Incabinet Dryer and Fluidized Bed Dryer. Jurnal Teknologi
Industri Pertanian, 25(1), 1–7.
Musmulya Putri, R., Eulis Diana, V., Fitri, K., Farmasi, M., Farmasi, F., Umum,
K., Kesehatan Helvetia, I., & Farmasi, D. (2019). The Comparison Of
Antibacterial Activity Test Of Ethanol Extract Of Flower, Leaf And Root Of
Rosella (Hibiscus sabdariffa L.) On Bacteria Staphylococcus aureus. In
Jurnal Dunia Farmasi (Vol. 3, Issue 3).
Nurfaradilla, S. A., Saputri, F. C., & Harahap, Y. (2019). Effects of Hibiscus
Sabdariffa Calyces Aqueous Extract on the Antihypertensive Potency of
Captopril in the Two-Kidney-One-Clip Rat Hypertension Model. EvidenceBased Complementary and Alternative Medicine, 2019.
Nwachukwu, D. C., Aneke, E., Nwachukwu, N. Z., Obika, L. F. O., Nwagha, U.
I., & Eze, A. A. (2015). Effect of Hibiscus sabdariffaon blood pressure and
electrolyte profile of mild to moderate hypertensive Nigerians: A
comparative study with hydrochlorothiazide. Nigerian Journal of Clinical
Practice, 18(6), 762–770. https://doi.org/10.4103/1119-3077.163278
Nwachukwu DC, Aneke E, Obika LFO, & NwachukwuNZ. (2015).Investigation
of Antihypertensive Effectiveness and Tolerability of Hibiscus Sabdariffa in
Mild to Moderate Hypertensive Subjects in Enugu, South-east, Nigeria.
OkerekeCN, I. F. C. M. (2015). Phytochemical analysis and medicinal uses of
Hibiscus sabdariffa. International Journal of Herbal Medicine, 2(6), 16–19.
Onyechi, T. O., Joshua, P., & Ikeyi, A. P. (2011). Phyochemical Analysis of
Aqueous Flower Extract of Hibiscus sadariffa (Zobo Flower).
Pahriyani, A., Dewanti, E., & Anggraeni, N. W. (2020). Aktivitas Fraksi Dari
Ekstrak Etanol 70% Daun Rosela (Hibiscus sabdariffa L.) Terhadap
Peningkatan Jumlah Eritrosit Tikus Anemia.
Sari Fita, aryantini Dyah. (2020). Karakterisasi Ekstrak Terpurifikasi Kelopak
Rosella (Hibiscsus sabdariffa L.) Dan Aktivitasnya Sebagai Antihipertensi
Pada Tikus Sprague Dawley. Jurnal Farmasi Desember, 12(2), 2085–4714.
Julianto ts. (2019). Fitokimia Tinjauan Metabolit Sekunder dan Skrining
Fitokimia. Hlm: 1 
Situmorang, R., Purba, H., Anjelina Simanjuntak, H. (2020). Phytochemical
screening of bunga rosella (Hibiscus sabdariffa L) and antimicrobial activity
test Phytochemical screening of bunga rosella (Hibiscus sabdariffa L) and
antimicrobial activity test Article history. Jurnal Pendidikan Kimia, 12(2),
70–78.
Subaryanti, Triawan, A., Masniari Poeloengan. (2013). Bunga Rosella (Hibiscus
sabdariffa L.) Sebagai Antibakteri (Rosella is as Antibacterial). 23(1), 1410–
7104.
Sulaiman, F. A., Kazeem, M. O., Waheed, A. M., Temowo, S. O., Azeez, I.O.,
Zubair, F. I., Adeyemi, T. A., Nyang, A., & Adeyemi, O. S. (2014).
Antimicrobial and toxic potential of aqueous extracts of Allium sativum,
Hibiscus sabdariffa and Zingiber officinale in Wistar rats. Journal of Taibah
University for Science, 8(4), 315–322.
Susilawati, Y., Soleha Rahmatullah, T., Muhtadi, A., Ferdiansyah Sofyan, F.,
Tjitraresmi, A., Raya Bandung Sumedang Km, J., & Sumedang, J. (n.d.).
Aktivitas Antihipertensi Ekstrak Kering Terstandarisasi Kelopak Bunga
Rosela (Hibiscus sabdariffa L.) Hasil Produksi Skala Pilot. Jurnal Sains Dan
Kesehatan. 2018, 1.
Tim Riskesdas 2018. (2018). Laporan nasional riskesdas 2018.
World Health Organization. (2021). Https://Www.Who.Int/News- Room/FactSheets/Detail/Hypertension.
Vangalpati, M., Padmaja & S. Surthi (2014). Hibiscus Sabdariffa – Avaluable
Herb. International Journal Of Pharmacy & Life sciences (8) 5.
Yulanda, G., & Lisiswanti, R. (2017). Glenys Yulanda dan Rika Lisiswanti |
Penatalaksanaan Hipertensi Primer Majority | Volume 6 | Nomor 1 |
Februari.
Yulita, R. F. (2021) ‘Jurnal Kesehatan Kartika Pada Pasien Hipertensi : Literatur
Review’, Jurnal Kesehatan Kartika, 16(1), pp. 9–16.
citation:   Angraini, Ega Deski dan Siska, Siska dan Hanani, Endang  (2022) REVIEW ARTIKEL: SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIHIPERTENSI ROSELA (HIBISCUS SABDARIFFA L.) TERHADAP PENURUNAN TEKANAN DARAH.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21974/1/FS03-220456.pdf