eprintid: 21886
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/18/86
datestamp: 2023-04-02 10:42:02
lastmod: 2023-04-02 10:42:02
status_changed: 2023-04-02 10:42:02
type: thesis
metadata_visibility: show
creators_name: Halimah, Latifah Nur
creators_name: Rachmania, Rizky Arcinthya
creators_name: Hariyanti, Hariyanti
title: KAJIAN SENYAWA BIOAKTIF SEBAGAI ANTI COVID TERHADAP
PENGHAMBATAN ENZIM MAIN PROTEASE (Mpro) SECARA VIRTUAL
SCREENING
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: COVID-19 adalah penyakit pernapasan akibat virus yang menyebabkan keadaan
darurat kesehatan global dan diumumkan sebagai penyakit pandemi oleh Organisasi
Kesehatan Dunia. Main protease (Mpro) merupakan reseptor penting dalam
memediasi replikasi dan transkripsi pada SARS-CoV-2, dan menjadi target penting
dalam penghambatan COVID-19. Tujuan penelitian ini adalah untuk
mengumpulkan dan mengkaji senyawa bioaktif dari tanaman herbal terhadap
reseptor main protease (Mpro) untuk mendapatkan hasil energi bebas ikatan yang
terbaik melalui virtual screening. Berdasarkan hasil studi literatur dapat
disimpulkan bahwa software yang paling baik adalah Autodock. Software ini
digunakan untuk mencari senyawa bioaktif yang memiliki potensi sebagai anti
covid dengan menggunakan enzim main protease (Mpro). Berdasarkan hasil
molecular docking diperoleh senyawa Theaflavin-3-3’-digallate dari golongan
fenol memiliki energi bebas ikatan terendah dengan nilai sebesar -12,41 kkal/mol
dibandingkan dengan senyawa pembanding yaitu lopinavir (-5,4 kkal/mol sampai -
9,70 kkal/mol)
Kata kunci : main protease, SARS-CoV-2, senyawa bioaktif, molecular docking,
kajian literatur
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Halimah, Latifah Nur dan Rachmania, Rizky Arcinthya dan Hariyanti, Hariyanti  (2022) KAJIAN SENYAWA BIOAKTIF SEBAGAI ANTI COVID TERHADAP PENGHAMBATAN ENZIM MAIN PROTEASE (Mpro) SECARA VIRTUAL SCREENING.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21886/1/FS03-220259.pdf