eprintid: 21834
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/18/34
datestamp: 2023-04-02 10:40:39
lastmod: 2023-04-02 10:40:39
status_changed: 2023-04-02 10:40:39
type: thesis
metadata_visibility: show
creators_name: Fadillah, Ade Aulia
creators_name: Hariyanti, Hariyanti
creators_name: Rachmania, Rizky Arcinthya
title: MOLECULAR DOCKING SENYAWA BIOAKTIF Justicia gendarussa
TERHADAP ENDORIBONUCLEASE (Nsp15) SARS COV-2
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Covid-19 merupakan penyakit yang disebabkan oleh SARS Cov-2, virus ini
rentan terhadap pH basa, asam kuat, dan stabil pada suhu 4 ºC. Penggunaan
tanaman herbal menjadi alternatif untuk pengobatan antivirus. Justicia
gendarussa secara in vitro memiliki kandungan senyawa yang dapat menurunkan
sejumlah virus. Penelitian bertujuan untuk memprediksi apakah senyawa Justicia
gendarussa dapat dijadikan sebagai anti SARS CoV-2 terhadap reseptor
Endoribonuclease (Nsp15). Mekanisme interaksi molekul antara ligan-reseptor
dapat dilakukan dengan metode molecular docking. Pada obat pembanding
Aprepitant nilai yang diperoleh sebesar -6,07 kcal/mol, Saquinavir -7,57 kcal/mol,
dan Valrubicin sebesar -7,53 kcal/mol. Untuk nilai energi bebas dari ligan asli
(CIT) yaitu sebesar -5,27 kcal/mol dan untuk ligan-ligan dari Justicia gendarussa
diambil 2 nilai senyawa uji terbaik yaitu (1R)−1,5-Anhydro-1-{3-[(4- carboxybenzoyl) (hydroxy)amino] propyl}-D-mannitol sebesar -7,60 kcal/mol dan
Justidrusamide CD sebesar -7,46 kcal/mol. Maka dapat disimpulkan bahwa
(1R)−1,5-Anhydro-1-{3-[(4-carboxybenzoyl)(hydroxy)amino] propyl}-D-mannitol
golongan flavonoid dan alkaloid dapat berinteraksi dan memiliki afinitas yang
baik dengan reseptor Endoribonuclease.
Kata kunci: Justicia gendarussa, Endoribonuclease (Nsp15), Sars cov 2.
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Fadillah, Ade Aulia dan Hariyanti, Hariyanti dan Rachmania, Rizky Arcinthya  (2022) MOLECULAR DOCKING SENYAWA BIOAKTIF Justicia gendarussa TERHADAP ENDORIBONUCLEASE (Nsp15) SARS COV-2.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21834/1/FS03-220234.pdf