eprintid: 21831
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/18/31
datestamp: 2023-04-02 10:36:10
lastmod: 2023-04-02 10:36:10
status_changed: 2023-04-02 10:36:10
type: thesis
metadata_visibility: show
creators_name: Hardiyanti, Utami Fitri
creators_name: Rachmania, Rizky Arcinthya
creators_name: Hariyanti, Hariyanti
title: PENAPISAN SENYAWA FITOTERAPEUTIK TERHADAP RESEPTOR
ENDORIBONUCLEASE SEBAGAI ANTI COVID-19 DENGAN SIMULASI
MOLECULAR DOCKING
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Covid-19 disebabkan oleh virus SARS-Cov-2. Penyebaran Covid-19 terhitung
cepat karena dapat tertular dari manusia ke manusia melalui percikan batuk/bersin
(droplet). Diketahui Endoribonuclease (nsp15) diperlukan untuk replikasi virus dan
kelangsungan hidupnya di sel inang. Penelitian ini bertujuan untuk memprediksi
senyawa Fitoterapeutik yang berpotensi sebagai antivirus SARS-Cov-2 terbaik
yang memiliki energi bebas Gibbs terendah dibanding ligan pembanding
(Aprepitant, Saquinavir, dan Valrubicin) sehingga dapat dijadikan kandidat
antivirus SARS-Cov-2. Dalam penelitian ini, pendekatan in-silico dalam
pengembangan obat digunakan untuk mencari senyawa fitoterapetik antivirus
potensial sebagai inhibitor terhadap protein replikasi SARS-Cov-2 dengan
menggunakan metode Molecular Docking. Aplikasi yang digunakan yaitu
Marvinsketch, Autodocktools, Discovery studio, Autodock 4.2, dan Pymol. Hasil
molecular docking menunjukan Pinusolidic acid dan 3'-(3-methylbut-2-enyl)-
3',4,7trihydroxyflavane memiliki energi bebas ikatan yang lebih kecil, masingmasing yaitu -8,39 kcal/mol dan -8,14 kcal/mol dibandingkan Aprepitant -6,48
kcal/mol, Saquinavir -6.73 kcal/mol, dan Valrubicin -7,09 kkal/mol sebagai ligan
pembanding. Maka dapat disimpulkan bahwa senyawa Pinusolidic acid dan 3'-(3-
methylbut-2-enyl)-3',4,7trihydroxyflavane sebagai senyawa fitoterapeutik yang
berpotensi sebagai antivirus Covid-19 dapat berinteraksi dan memiliki afinitas
pengikatan yang baik dengan reseptor Endoribonuclease (nsp15).
Kata kunci : anti Covid-19, endoribonuclease, fitoterapeutik, molecular docking.
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Hardiyanti, Utami Fitri dan Rachmania, Rizky Arcinthya dan Hariyanti, Hariyanti  (2022) PENAPISAN SENYAWA FITOTERAPEUTIK TERHADAP RESEPTOR ENDORIBONUCLEASE SEBAGAI ANTI COVID-19 DENGAN SIMULASI MOLECULAR DOCKING.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21831/1/FS03-220232.pdf