eprintid: 21830
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/18/30
datestamp: 2023-04-02 10:36:05
lastmod: 2023-04-02 10:36:05
status_changed: 2023-04-02 10:36:05
type: thesis
metadata_visibility: show
creators_name: Fawziah, Syifa
creators_name: Hariyanti, Hariyanti
creators_name: Rachmania, Rizky Arcinthya
title: MOLECULAR DOCKING SENYAWA BIOAKTIF Justicia gendarussa
TERHADAP SPIKE PROTEIN SARS-CoV-2
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: SARS-CoV-2 merupakan salah satu wabah penyakit yang menyerang sistem
pernapasan. Pengobatan pada SARS-CoV-2 belum diketahui obat yang disetujui
untuk infeksi SARS-CoV, MERS-CoV dan SARS-CoV-2 yang menginfeksi pada
manusia. Tujuan penelitian ini untuk mengetahui kandungan senyawa pada tanaman
gandarussa (Justicia gendarussa) sebagai antivirus terhadap reseptor spike protein
melalui molecular docking. Tanaman Justicia gendarussa memiliki aktivitas
sebagai antivirus. Namun belum diketahui senyawa kandungan Justicia gendarussa
dapat menghambat aktivitas antivirus pada SARS-CoV-2. Metode penambatan yang
digunakan pada penelitian ini menggunakan molecular docking dengan aplikasi
bantuan Discovery studio Visualizer untuk preparasi makromolekul reseptor,
Marvin Sketch untuk preparasi ligan dan AutodockTools 1.5.6 untuk penambatan
molecular terhadap reseptor dengan ligan. Hasil penelitian senyawa tanaman
Justicia gendarussa yaitu Dihydromonacolin L acid menghasilkan nilai energi
bebas terbaik dengan -7,93 (kkal/mol). Jika dibandingkan dengan senyawa
pembanding obat chloroquine dan hydroxychloroquine memiliki nilai energi bebas
(ΔG) sebesar -4,11 (kkal/mol) dan -3,07 (kkal/mol). Hasil menunjukkan senyawa
tanaman Justicia gendarussa Dihydromonacolin L acid memiliki afinitas
pengikatan lebih baik dalam pengembangan obat untuk antivirus pada SARS-CoV-2.
Kata Kunci: SARS-CoV-2, Justicia gendarussa, Spike Protein, Molecular
Docking.
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Fawziah, Syifa dan Hariyanti, Hariyanti dan Rachmania, Rizky Arcinthya  (2022) MOLECULAR DOCKING SENYAWA BIOAKTIF Justicia gendarussa TERHADAP SPIKE PROTEIN SARS-CoV-2.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21830/1/FS03-220231.pdf