eprintid: 21794
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/17/94
datestamp: 2023-04-02 10:34:26
lastmod: 2023-04-02 10:34:26
status_changed: 2023-04-02 10:34:26
type: thesis
metadata_visibility: show
creators_name: Algifari, Abu Rijal
creators_name: Nining, Nining
creators_name: Nursal, Fith Khaira
title: PENGARUH pH TERHADAP PROFIL DIFUSI PIROKSIKAM DARI
HIDROGEL POLIELEKTROLIT BERBASIS NATRIUM ALGINAT DAN
TRAGAKAN MELALUI IONTOFORESIS
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Piroksikam merupakan senyawa anti inflamasi non-steroid (AINS) yang banyak
digunakan dalam terapi rheumatoid arthritis dan osteoarthritis. Efek samping
piroksikam yang mengiritasi lambung jika diberikan secara oral dapat diatasi
melalui pemberian sediaan transdermal. Pada penelitian ini telah dikembangkan
sediaan hidrogel piroksikam yang dihantarkan dengan metode iotoforesis yang
dipengaruhi proses ionisasi dalam pelepasan zat aktif. Hidrogel dibuat dengan
komponen formula yang tersusun dari polimer polielektrolit ionik dan dibentuk
melalui jaringan polimer yang berikatan silang dengan gugus yang dapat
terionisasi pada fase cair. Polimer yang digunakan adalah kombinasi natrium
alginat dan tragakan. Penelitian bertujuan mengetahui pengaruh variasi pH
sediaan terhadap profil difusi hidrogel piroksikam yang dilepaskan dengan
metode iontoforesis. Sediaan dibuat 4 formula dengan variasi pH; F1 (pH 4,2), F2
(pH 5,5), F3 (pH 6,4), dan F4 (pH 7,4). Evaluasi sediaan secara organoleptis
berbentuk semisolid berwarna kuning, tidak berbau dan homogen. Nilai daya
sebar yang diperoleh adalah dibawah 5 cm menandakan sediaan semistiff (semi
kaku). Nilai konduktivitas yang diberikan masing-masing formula adalah F1 =
9,58 ms/cm , F2 = 7,88 ms/cm, F3 = 7,73 ms/cm, dan F4 = 8,01 ms/cm.
Pengujian difusi secara in vitro menggunakan sel difusi Franz yang diberikan
anoda Ag dan katoda AgCl pada sel dengan arus listrik 2 Voltage selama 7 jam.
Diperoleh hasil difusi sebagai berikut; F1 = 634,5238 μg/cm2
 (nilai terbesar)
diikuti F2 = 427,9113 μg/cm2
, F3 = 205,7650 μg/cm2
, dan F4 = 253,5550 μg/cm2
.
Hasil penelitian menunjukkan bahwa difusi hidrogel piroksikam dipengaruhi nilai
pH sediaan dan F1 dengan nilai pH terendah (4,2) memberikan jumlah zat
terdifusi paling tinggi.
Kata Kunci : piroksikam, hidrogel, iontoforesis, pH, difusi
date: 2021
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Algifari, Abu Rijal dan Nining, Nining dan Nursal, Fith Khaira  (2021) PENGARUH pH TERHADAP PROFIL DIFUSI PIROKSIKAM DARI HIDROGEL POLIELEKTROLIT BERBASIS NATRIUM ALGINAT DAN TRAGAKAN MELALUI IONTOFORESIS.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21794/1/FS03-220055.pdf