eprintid: 21734
rev_number: 10
eprint_status: archive
userid: 3858
dir: disk0/00/02/17/34
datestamp: 2023-04-02 10:29:25
lastmod: 2023-04-02 10:29:25
status_changed: 2023-04-02 10:29:25
type: thesis
metadata_visibility: show
creators_name: Ibrahim, Ibrahim
creators_name: Gusmayadi, Inding
creators_name: Prisiska, Fahjar
title: PENGARUH PENGGUNAAN PATI SUKUN (Artocarpus altilis (Parkinson)
Fosberg.) TERPRAGELATINASI SEBAGAI SUPERDISINTEGRAN PADA
ORALLY DISINTEGRATING TABLETS METOKLOPRAMID
HIDROKLORIDA
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Metoklopramid HCl berkhasiat sebagai antiemetik yang membutuhkan efek cepat,
sehingga sangat efektif dibuat dalam orally disintegrating tablet. Penelitian ini
menggunakan pati sukun terpragelatinasi sebagai superdisintegran. Tujuan
penelitian ini untuk mengetahui apakah pati sukun terpragelatinasi dapat dijadikan
sebagai superdisintegran dalam formulasi orally disintegrating tablet.
Superdisintegran dibuat menjadi 3 konsentrasi berbeda dalam 5 formula yaitu 5%,
7%, 9%, dan Sodium Startch 10% dan pembanding blanko dengan metode kempa
langsung. Uji yang dilakukan meliputi kekerasan, keregasan, keseragaman ukuran,
keseragaman bobot, waktu hancur termodifikasi dan evaluasi kimia tablet. Hasil
evaluasi uji kekerasan yaitu F1:2,466 Kg/cm2, F2:2,57 Kg/cm2, F3:2,68 Kg/cm2,
F4:4,20 Kg/cm2 dan F5:2,97 Kg/cm2. Hasil evaluasi uji keregasan yaitu F1:0,69%,
F2:0,68%, F3:0,70%, F4:0,65% dan F5:0,68%. Hasil evaluasi uji waktu hancur
yang diperoleh yaitu F1:26,00 detik, F2:20,94 detik, F3:18,00 detik, F4:119,827
detik dan F5:60,2386 detik. Hasil analisa statistik ANOVA satu arah menunjukkan
adanya perbedaan bermakna. Dapat disimpulkan bahwa pati sukun terpragelatinasi
dapat dijadikan superdisintegran dalam formulasi orally disintegrating tablet
metoklopramid HCl dan menghasilkan sifat fisik yang memenuhi persyaratan.
Kata Kunci: Sukun, Pati Sukun, Pragelatinisasi, Superdisintegrant, Orally
Disintegrating Tablets.
date: 2019
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Ibrahim, Ibrahim dan Gusmayadi, Inding dan Prisiska, Fahjar  (2019) PENGARUH PENGGUNAAN PATI SUKUN (Artocarpus altilis (Parkinson) Fosberg.) TERPRAGELATINASI SEBAGAI SUPERDISINTEGRAN PADA ORALLY DISINTEGRATING TABLETS METOKLOPRAMID HIDROKLORIDA.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21734/1/FS03-220378.pdf