eprintid: 21704
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/17/04
datestamp: 2023-04-02 10:27:28
lastmod: 2023-04-02 10:27:28
status_changed: 2023-04-02 10:27:28
type: thesis
metadata_visibility: show
creators_name: Indriana, Sekar Mufidah
creators_name: Hikmawanti, Ni Putu Ermi
creators_name: Hanani, Endang
title: ULASAN PENENTUAN KUANTITATIF FENOLIK PADA BEBERAPA
TUMBUHAN ASTERACEAE DARI EKSTRAKSI DENGAN BANTUAN
ULTRASONIC DAN MICROWAVE
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Asteraceae merupakan keluarga tumbuhan berbunga terbesar yang memiliki
berbagai macam metabolit sekunder terutama senyawa fenolik yang sudah banyak
dimanfatkan sebagai obat tradisional sejak dulu. Senyawa fenolik tersebut dapat
diekstraksi dengan metode ekstraksi non konvensional yaitu Ultrasonic Assisted
Extraction (UAE) dan Microwave Assisted Extraction (MAE). Penelitian ini
merupakan ulasan artikel dalam bentuk narrative review yang membahas tentang
bagaimana penentuan kuntitatif senyawa fenolik dari Asteraceae yang diekstraksi
menggunakan metode UAE dan MAE. Dari hasil pengulasan pustaka, dapat
ditarik kesimpulan bahwa tumbuhan Asteraceae memiliki senyawa fenolik yang
dapat diekstraksi dengan metode UAE dan MAE. Metode ini cukup efisien dan
memiliki banyak keuntungan serta dapat dikembangkan untuk skala industri.
Kata Kunci: Asteraceae, Ekstraksi, Fenolik, MAE, Narrative Review, UAE.
date: 2021
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
referencetext: Achika JI, Arthur DE, Gerald I, Adedayo A. 2014. A Review on the
Phytoconstituents and Related Medicinal Properties of Plants in the
Asteraceae Family A Review on the Phytoconstituents and Related
Medicinal Properties of Plants in the Asteraceae Family. IOSR Journal of
Applied Chemistry, 7(8).
Aghraz A, Gonçalves S, Rodríguez-Solana R, Dra LA, Di Stefano V, Dugo G,
Cicero N, Larhsini M, Markouk M, Romano A. 2018. Antioxidant activity
and enzymes inhibitory properties of several extracts from two Moroccan
Asteraceae species. South African Journal of Botany, 118, Hlm. 58–64.
Ak G, Zengin G, Sinan KI, Mahomoodally M, Picot-Allain MCN, Cakir O,
Bensari S, Yilmaz MA, Gallo M, Montesano D. 2020. A comparative bioevaluation and chemical profiles of Calendula officinalis L. extracts prepared
via different extraction techniques. Applied Sciences (Switzerland), 10(17).
Akhtar I, Javad S, Yousaf Z, Iqbal S, Jabeen K. 2019. Microwave assisted
extraction of phytochemicals an efficient and modern approach for botanicals
and pharmaceuticals. Pakistan Journal of Pharmaceutical Sciences, 32(1),
Hlm. 223–230.
Alara OR, Abdurahman NH, Olalere OA. 2020. Ethanolic extraction of
flavonoids, phenolics and antioxidants from Vernonia amygdalina leaf using
two-level factorial design. Journal of King Saud University - Science, 32(1).
Hlm. 7–16.
Alara OR, Abdurahman NH, Mudalip SKA, Olalere OA. 2019. Effects of
microwave-assisted extraction parameters on the recovery yield and total
phenolic content of vernonia amygdalina leaf extracts with different methods
of drying. Jundishapur Journal of Natural Pharmaceutical Products, 14(1).
Hlm. 1–11.
Andressa B, G. C. L. and J. C. P. de M. 2013. Application and Analysis of the
Folin Ciocalteu Method for the Determination of the Total Phenolic Content
from Limonium Brasiliense L. Molecul, 18. Hlm. 6852–6864.
Aourach M, González-De-peredo AV, Vázquez-Espinosa M, Essalmani H, Palma
M, Barbero GF. 2021. Optimization and comparison of ultrasound and
microwave-assisted extraction of phenolic compounds from cotton-lavender
(Santolina chamaecyparissus l.). Agronomy, 11(1).
Basli A, Belkacem N, Amrani I. 2017. Health Benefits of Phenolic Compounds
Against Cancers. In Phenolic Compounds - Biological Activity. InTech.
Bener M. 2020. Modeling and Optimizing of Microwave-Assisted Extraction of
Antioxidants and Phenolics from Wormwood (Artemisia absinthium L.)
Using Response Surface Methodology. Journal of the Institute of Science
and Technology, 10(1). Hlm. 357–367.
Covarrubias-Cárdenas AG, Martínez-Castillo JI, Medina-Torres N, AyoraTalavera T, Espinosa-Andrews H, García-Cruz NU, Pacheco N. 2018.
Antioxidant capacity and uplc-pda esi-ms phenolic profile of stevia
rebaudiana dry powder extracts obtained by ultrasound assisted extraction.
Agronomy, 8(9).
Cronin P, Ryan F, Coughlan M. 2008. Undertaking a literature review: a step-bystep approach. British Journal of Nursing, 17(1), 38–43.
Departemen Kesehatan Republik Indonesia. 2017. Farmakope Herbal Indonesia
Edisi II. In Farmakope Herbal Indonesia (p. 6).
Farahani ZK. 2021. The effect of extraction method ( ultrasonic , maceration , and
soxhlet ) and solvent type on the extraction rate of phenolic compounds and
extraction efficiency of Arctium lappa L . roots and Polygonum aviculare L .
grass. Food & Health, 4(2) Hlm. 28–34.
Francavilla M, Marone M, Marasco P, Contillo F, Monteleone M. 2021.
Artichoke biorefinery: From food to advanced technological applications.
Foods, 10(1).
Guss KL, Pavanni S, Prati B, Dazzi L, de Oliveira JP, Nogueira BV, Pereira
TMC, Fronza M, Endringer DC, Scherer R. 2017. Ultrasound-assisted
extraction of Achyrocline satureioides prevents contrast-induced
nephropathy in mice. Ultrasonics Sonochemistry, 37. Hlm. 368–374.
Hanani E. 2015. Analisis Fitokima. Penerbit Buku Kedokteran EGC, Jakarta.
Hashemi Z, Ebrahimzadeh MA, Khalili M. 2019. Sun protection factor, total
phenol, flavonoid contents and antioxidant activity of medicinal plants from
iran. Tropical Journal of Pharmaceutical Research, 18(7). Hlm. 1443–1448.
Joujeh R. 2020. Phytochemical Analysis, Total Phenolic Content, Hemolytic and
Antihemolytic Activities of Centaurea iberica (Asteraceae). Basic and
Applied Sciences - Scientific Journal of King Faisal University, 1. Hlm. 35–
43.
Kayahan S, Saloglu D. 2020. Optimization and kinetic modelling of microwaveassisted extraction of phenolic contents and antioxidants from Turkish
artichoke. CYTA - Journal of Food, 18(1). Hlm. 635–643.
Kollia E, Markaki P, Zoumpoulakis P, Proestos C. 2017. Comparison of different
extraction methods for the determination of the antioxidant and antifungal
activity of cynara scolymus and c. cardunculus extracts and infusions.
Natural Product Communications, 12(3). Hlm. 423–426. 
Kumar K, Srivastav S, Singh V. 2021. Ultrasonics - Sonochemistry Ultrasound
assisted extraction ( UAE ) of bioactive compounds from fruit and vegetable
processing by-products : A review. Ultrasonics - Sonochemistry, 70, 105325.

Laouini SE, Kelef A, Ouahrani MR. 2018. Free radicals scavenging activity and
phytochemical composition of astermisia (Herba-Alba) extract growth in
Algeria. Journal of Fundamental and Applied Sciences, 10(1), 268.
Latiff NA, Ong PY, Abd Rashid SNA, Abdullah LC, Mohd Amin NA, Fauzi
NAM. 2021. Enhancing recovery of bioactive compounds from Cosmos
caudatus leaves via ultrasonic extraction. Scientific Reports, 11(1). Hlm. 1–
12.
Latiff NA, Ong PY, Abdullah LC, Nor S, Abd A. 2021. Ultrasonic-Assisted
Extraction ( UAE ) for Enhanced Recovery of Bioactive Phenolic
compounds from Cosmos Caudatus leaves. Research Square. Hlm. 4–6.
Marzali A. 2017. Menulis Kajian Literatur. ETNOSIA : Jurnal Etnografi
Indonesia, 1(2), 27.
Momchev P, Ciganović P, Jug M, Marguí E, Jablan J, Zovko Končić M. 2020.
Comparison of Maceration and Ultrasonication for Green Extraction of
Phenolic Acids from Echinacea purpurea Aerial Parts. Molecules (Basel,
Switzerland), 25(21).
Nizioł-ŁUkaszewska Z, Furman-Toczek D, Zagórska-Dziok M. 2018.
Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and
leaves extract on HaCaT and BJ fibroblast cells. Lipids in Health and
Disease, 17(1). Hlm. 1–12.
Petkova N, Ivanov I, Vrancheva R, Denev P, Pavlov A. 2017. Ultrasound and
microwave-assisted extraction of elecampane (Inula helenium) roots. Natural
Product Communications, 12(2). Hlm. 171–174.
Putranto AW, Dewi SR, Izza N, Yuneri DR, Danchi MSY, Sumarlan SH. 2018.
Rona Teknik Pertanian, 11 (1) April 2018. Rona Teknik Pertanian, 11(1),
Hlm. 59–70.
Ramdhani A, Ramdhani MA, Amin AS. 2014. Writing a Literature Review
Research Paper: A step-by-step approach. International Journal of Basic and
Applied Science, 3(1). Hlm. 47–56.
Rolnik A, Olas B. 2021. The Plants of the Asteraceae Family as Agents in the
Protection of Human Health. International Journal of Molecular Sciences,
22(6), 3009.
Salarbashi D, Khanzadeh F, Hosseini SM, Mohamadi M, Rajaei A, Garmakhany,
AD. 2014. Prediction of the extraction yield using artificial neural network
and response surface methodology: Ultrasound-assisted extraction from
Achillea berbresteinii L. Quality Assurance and Safety of Crops and Foods,
6(4). Hlm. 431–438.
Salarbashi D, Fazly Bazzaz BS, Sahebkar A, Karimkhani MM, Ahmadi A. 2012.
Investigation of optimal extraction, antioxidant, and antimicrobial activities
of Achillea biebersteinii and A. wilhelmsii. Pharmaceutical Biology, 50(9).
Hlm. 1168–1176.
Salarbashi D, Mortazavi SA, Rezaei K, Rajaei A, Karimkhani MM. 2012.
Optimization of ultrasound-assisted extraction of phenolic compounds from
yarrow (Achillea beibrestinii) by response surface methodology. Food
Science and Biotechnology, 21(4),. Hlm. 1005–1011.

Sirijeerachai G, Khunasinkun S, Boonleau P, Oonsivilai R, Nuchitprasitchai A.
2021. Optimization of Ultrasonic-assisted Extraction of Total Phenolic
Compound from Leaves of Chromolaena Odorata L. Using Response Surface
Methodology. MATEC Web of Conferences, 333, 06005.
Snyder H. 2019. Literature review as a research methodology : An overview and
guidelines. Journal of Business Research, 104. Hlm. 333–339.
Souhila T, Fatma ZB, Tahar HS. 2019. Identification and quantification of
phenolic compounds of Artemisia herba-alba at three harvest time by HPLC–
ESI–Q-TOF–MS. International Journal of Food Properties, 22(1). Hlm.
843–852.
Souri M, Shakeri A. 2018. Optimization of Total Phenol and Tannin Content and
Biological Activity of Dittrichia graveolens (L.) GREUTER. . Current
Bioactive Compounds, 16(2). Hlm. 124–132.
Stankov S, Fidan H, Petkova N, Stoyanova A, Dincheva I, Dogan H, Senkal B,
Uskutoglu T, Bas H, Yilmaz G. 2020. Phytochemical composition of
Нelichrysum arenarium (L.) Moench essential oil (aerial parts) from Turkey.
Ukrainian Food Journal, 9(3). Hlm. 503–512.
Subhash CM, Vivekananda Mandal AKDas. 2015. Essentials of Botanical
Extractions: Principle and Applications. Elsevier Inc.
Tadesse M. 2015. How to study the Asteraceae.pdf. Ethiopian Journal of
Biological Sciences, 13(October).
Tanase C, Cosarcă S, Muntean DL. 2019. A critical review of phenolic
compounds extracted from the bark of woody vascular plants and their
potential biological activity. Molecules, 24(6).
Tradit AJ, Altern C, Sasidharan S, Chen Y, Saravanan D, Sundram KM, Latha
LY, Bedong-semeling J, Nasi BA. 2011. EXTRACTION , ISOLATION AND 
CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM PLANTS ’
EXTRACTS Institute for Research in Molecular Medicine ( INFORM ),
Universiti Sains Malaysia , Minden 11800 ,. 8(1). Hlm. 1–10.
Villalva M, Santoyo S, Salas-Pérez L, Siles-Sánchez M de las N, García-Risco
MR, Fornari T, Reglero G, Jaime L. 2021. Sustainable extraction techniques
for obtaining antioxidant and anti-inflammatory compounds from the
lamiaceae and asteraceae species. Foods, 10(9).
Vinatoru M, Mason TJ, Calinescu I. 2017. Ultrasonically assisted extraction
(UAE) and microwave assisted extraction (MAE) of functional compounds
from plant materials. TrAC Trends in Analytical Chemistry, 97. Hlm. 159–
178.
Vuolo MM, Lima VS, Maróstica Junior MR. 2018. Phenolic Compounds:
Structure, Classification, and Antioxidant Power. In Bioactive Compounds:
Health Benefits and Potential Applications. Elsevier Inc.
Wang J, Zhao YM, Guo CY, Zhang SM, Liu CL, Zhang DS, Bai XM. 2012.
Ultrasound-assisted extraction of total flavonoids from Inula helenium.
Pharmacognosy Magazine, 8(30). Hlm. 166–170.
Watson RR. 2014. Polyphenols in Plants. In Polyphenols in Plants: Isolation,
Purification and Extract Preparation. Elsevier.
Zeb A. 2020. Concept, mechanism, and applications of phenolic antioxidants in
foods. Journal of Food Biochemistry, 44(9). Hlm. 1–22.
Zhang QW, Lin LG, Ye WC. 2018. Techniques for extraction and isolation of
natural products: A comprehensive review. Chinese Medicine (United
Kingdom), 13(1). Hlm. 1–26.
Zoumpoulakis P, Sinanoglou VJ, Siapi E, Heropoulos G, Proestos C. 2017.
Evaluating modern techniques for the extraction and characterisation of
sunflower (Hellianthus annus L.) seeds phenolics. Antioxidants, 6(3).
citation:   Indriana, Sekar Mufidah dan Hikmawanti, Ni Putu Ermi dan Hanani, Endang  (2021) ULASAN PENENTUAN KUANTITATIF FENOLIK PADA BEBERAPA TUMBUHAN ASTERACEAE DARI EKSTRAKSI DENGAN BANTUAN ULTRASONIC DAN MICROWAVE.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21704/1/FS03-220230.pdf