eprintid: 21701
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/17/01
datestamp: 2023-04-02 10:27:08
lastmod: 2023-04-02 10:27:08
status_changed: 2023-04-02 10:27:08
type: thesis
metadata_visibility: show
creators_name: Luthfiyyah, Ade Nurul
creators_name: Hariyanti, Hariyanti
creators_name: Rachmania, Rizky Arcinthya
title: MOLECULAR DOCKING SENYAWA BIOAKTIF Justicia gendarussa
TERHADAP MAIN PROTEASE (Mpro) SARS-CoV-2
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Penyakit COVID-19 yang disebabkan oleh virus SARS-CoV-2 telah menjadi
penyakit pandemic global terbesar pada tahun 2020. Penelitian ini bertujuan untuk
memprediksi senyawa bioaktif Justicia gendarussa sebagai anti-covid terhadap
reseptor Main protease (Mpro) melalui molecular docking. Mekanisme interaksi
molekul antara ligan-reseptor dapat dilakukan melalui metode molecular docking
dengan software Autodock 4.2. Ligan ditambatkan pada reseptor Main Protease
(Mpro). Analisis interaksi ikatan ligan dengan reseptor menggunakan software
Pymol. Hasil penambatan molekul pada senyawa ligan Justicia gendarussa
terhadap reseptor Main protease (Mpro), diperoleh dua senyawa terbaik, yaitu
Justidrusamide E dan Dihydromonacolin L Acid yang memiliki nilai energi bebas
terendah sebesar -7,17 kcal/mol dan -7,10 kcal/mol. Bentuk interaksi yang terjadi
pada Justidrusamide E adalah adanya ikatan hydrogen dengan residu Gly 143, Cys
145, Glu 166, His 163, Met 165, Arg 188, dan Gln 189. Kemudian bentuk
interaksi yang terjadi pada Dihydromonacolin L Acid adalah adanya ikatan
hydrogen dengan residu Ser 144, His 163, dan Glu 166. Hasil ini membuktikan
bahwa senyawa Justidrusamide E dan Dihydromonacolin L Acid dari ekstrak
etanol daun Justicia gendarussa dapat berpotensi sebagai anti-covid terhadap
reseptor Main Protease (Mpro) melalui molecular docking.
Kata Kunci : Main Protease (Mpro), Molecular Docking, Justicia gendarussa,
SARS-CoV-2.
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Luthfiyyah, Ade Nurul dan Hariyanti, Hariyanti dan Rachmania, Rizky Arcinthya  (2022) MOLECULAR DOCKING SENYAWA BIOAKTIF Justicia gendarussa TERHADAP MAIN PROTEASE (Mpro) SARS-CoV-2.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21701/1/FS03-220227.pdf