eprintid: 21651
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/16/51
datestamp: 2023-04-02 10:23:53
lastmod: 2023-04-02 10:23:53
status_changed: 2023-04-02 10:23:53
type: thesis
metadata_visibility: show
creators_name: Delima, Dwi Fanny
creators_name: Amalia, Anisa
creators_name: Nining, Nining
title: PENGARUH VARIASI KONSENTRASI SODIUM STARCH GLYCOLATE
SEBAGAI PENGHANCUR TERHADAP SIFAT FISIK DAN DISOLUSI
FILM SALBUTAMOL SULFAT DENGAN POLIMER GUAR GUM
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Orally dissolving film (ODF) merupakan film yang ketika diletakkan dibawah lidah
akan terdisintegrasi serta melepaskan zat aktif secara cepat dengan bantuan saliva.
Komponen orally dissolving film (ODF) yang mempengaruhi pelepasan zat aktif
dari sediaan yaitu superdisintegrant salah satunya adalah sodium Starch glycolate
(SSG). Tujuan penelitian ini untuk mengetahui pengaruh penggunaan variasi
konsentrasi terhadap sifat fisik dan disolusi film. dengan konsentrasi 1%, 1,5%, 2%
diformulasikan dalam film yang dibuat dengan Solvent Casting Methode. Evaluasi
yang dilakukan meliputi organoleptis, uji pH, ketebalan film, ketahanan lipat,
moisture uptake, keseragaman kandungan, waktu hancur, dan uji disolusi. Film
yang dihasilkan berwarna kuning, sedikit kering, homogen, transparan, kadar zat
aktif salbutamol dalam film 95,9%-99,2%, ketebalan film 0,03-0,04 mm, pH film
6,9-7,18, kelembapan film 14%-23%, daya tahan lipat 110-765 kali, waktu hancur
film 26–72 detik. Data waktu hancur termasuk normal dan homogen sehingga
dilakukan uji ANOVA satu arah, hasil didapat nilai sig. 0,00>0,05 yang berarti ada
perbedaan bermakna waktu hancur pada film dengan variasi konsentrasi SSG. Uji
lanjut Tukey memperlihatkan signifikansi perbedaan antar tiap formula. Pada
pengujian statistik terhadap data disolusi hasil yang didapat dari uji normalitas dan
homogenitas tidak homogen hasil didapat nilai sig. 0,00<0,05 dan dilanjutkan
dengan uji Friedmen sebagai uji alternatif. Dapat disimpulkan bahwa penggunaan
SSG mempercepat waktu hancur dan disolusi film salbutamol. Semakin tinggi
konsentrasi SSG maka waktu hancur semakin tinggi.
Kata kunci : Orally Dissolving Film, Sodium Starch Glycolate, Salbutamol Sulfat
date: 2022
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Delima, Dwi Fanny dan Amalia, Anisa dan Nining, Nining  (2022) PENGARUH VARIASI KONSENTRASI SODIUM STARCH GLYCOLATE SEBAGAI PENGHANCUR TERHADAP SIFAT FISIK DAN DISOLUSI FILM SALBUTAMOL SULFAT DENGAN POLIMER GUAR GUM.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21651/1/FS03-220183.pdf