eprintid: 21637
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/16/37
datestamp: 2023-04-02 10:23:49
lastmod: 2023-04-02 10:23:49
status_changed: 2023-04-02 10:23:49
type: thesis
metadata_visibility: show
creators_name: Sari, Devi Puspita
creators_name: Lestari, Pramulani Mulya
creators_name: Nining, Nining
title: REVIEW: KOMPOSIT POLIMER PEKTIN DALAM
SISTEM PENGHANTARAN OBAT
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Pektin merupakan polisakarida yang berlimpah di alam dan memiliki kegunaan
yang menjanjikan dalam bidang farmasi. Pektin tahan terhadap enzim pencernaan
namun gel pektin dapat membengkak dalam media berair dan sejumlah kecil
senyawa dapat dilepaskan ke saluran gastrointestinal. Masalah ini dapat diatasi
dengan mengembangkan komposit pektin yang diperoleh dari penggabungan
polimer pektin dengan polimer lain. Artikel ini membahas tentang interaksi pektin
dengan polimer lain dalam berbagai sistem penghantaran obat. Metode penelitian
ini menggunakan desain penelitian narrative review yaitu dengan meninjau jurnal
ilmiah yang diterbitkan secara nasional dan internasional yang diperoleh dari
Google, Google Scholar, Pubmed dan Science Direct dengan kata kunci
menggunakan Bahasa Indonesia dan Bahasa Inggris berupa “komposit polimer”,
“komposit pektin”, “pektin”, “sistem penghantaran obat”, “pectin”, ”pectin
composite”, “polimer composite”, dan “drug delivery system”. Literatur yang
digunakan kemudian dilakukan skrining jurnal dengan kriteria inklusi yaitu waktu
terbit dengan rentang tahun 2011-2021. Dari beberapa penelitian terkait, sistem
penghantaran yang telah dikembangkan dan dilaporkan berupa film, hidrogel,
sistem partikulat dan tablet. Komposit pektin dapat meningkatkan profil mekanik,
dan kapasitas penyerapan luka sehingga dapat digunakan sebagai polimer dalam
pembalut luka, selain itu komposit pektin juga dapat digunakan sebagai
penghantaran obat spesifik ke kolon. Berdasarkan review jurnal yang telah
dilakukan, komposit pektin dapat dikembangkan dalam sistem penghantaran obat
spesifik ke kolon serta sebagai pembalut luka, sehingga komposit pektin dapat
menjadi peluang di masa yang akan datang.
Kata kunci: Pektin, Komposit Pektin, Sistem Penghantaran Obat, Narrative
Review
date: 2021
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Sari, Devi Puspita dan Lestari, Pramulani Mulya dan Nining, Nining  (2021) REVIEW: KOMPOSIT POLIMER PEKTIN DALAM SISTEM PENGHANTARAN OBAT.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21637/1/FS03-220033.pdf