eprintid: 21611
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/16/11
datestamp: 2023-04-02 10:20:12
lastmod: 2023-04-02 10:20:12
status_changed: 2023-04-02 10:20:12
type: thesis
metadata_visibility: show
creators_name: Wahyuni, Sri
creators_name: Kusmardi, Kusmardi
creators_name: Rusdi, Numlil Khaira
title: AKTIVITAS EKSTRAK ETANOL 70% KULIT BUAH DELIMA (Punica
granatum L.) TERHADAP EKSPRESI PROTEIN CASPASE-3 PADA
JARINGAN KANKER KOLON MENCIT
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Pemanfaatan tanaman herbal sebagai agen terapi kanker saat ini telah banyak
digunakan oleh masyarakat. Salah satu tanaman yang berpotensi sebagai
antikanker adalah kulit buah delima (Punica granatum L.). Kulit buah delima
diketahui memiliki kandungan ellagitanin, asam elagat, dan asam galat yang
berkhasiat sebagai antikanker. Penelitian ini bertujuan untuk mengetahui aktivitas
ekstrak etanol 70% kulit buah delima (Punica granatum L.) terhadap ekspresi
protein caspase-3 pada jaringan kanker kolon mencit sebagai parameter terjadinya
apoptosis. Pengujian dilakukan dengan menggunakan teknik pewarnaan
imunohistokimia. Persentase sel yang mengekspresikan caspase-3 (tampak
sebagai warna coklat) dihitung dengan bantuan Image-J dan IHC Profiler
selanjutnya dianalisa dengan one way ANOVA. Hasil penelitian menunjukkan
pada kelompok dosis II yang diberi ekstrak kulit buah delima dosis 480
mg/kgBB/hari dan DSS 2% mampu meningkatkan ekspresi protein caspase-3
lebih tinggi dibandingkan dengan kelompok dosis I yang diberi ekstrak kulit buah
delima dosis 240 mg/kgBB/hari dan DSS 2%.
Kata Kunci: Caspase-3, Imunohistokimia (IHK), Kanker kolon, Kulit Buah
Delima.
date: 2020
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Wahyuni, Sri dan Kusmardi, Kusmardi dan Rusdi, Numlil Khaira  (2020) AKTIVITAS EKSTRAK ETANOL 70% KULIT BUAH DELIMA (Punica granatum L.) TERHADAP EKSPRESI PROTEIN CASPASE-3 PADA JARINGAN KANKER KOLON MENCIT.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21611/1/FS03-220009.pdf