eprintid: 21443
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/14/43
datestamp: 2023-02-20 08:29:44
lastmod: 2023-02-20 08:29:44
status_changed: 2023-02-20 08:29:44
type: thesis
metadata_visibility: show
creators_name: ADAWIYAH, SITI ROBIATUL
creators_name: Nining, Nining
creators_name: Amalia, Anisa
title: PENGARUH PENGGUNAAN ASAM OLEAT SEBAGAI PENINGKAT
PENETRASI TERHADAP SIFAT FISIK DAN DIFUSI SEDIAAN PATCH
TRANSDERMAL DISPERSI PADAT MELOKSIKAM
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Meloksikam memiliki efek samping gastrointestinal jika digunakan secara oral,
untuk mencegah efek tersebut maka dibuat patch transdermal. Patch transdermal
merupakan bentuk sediaan yang dapat menghantarkan obat melalui kulit. Sediaan
patch transdermal memiliki bahan tambahan yaitu peningkat penetrasi yang
berfungsi meningkatkan penetrasi obat ke dalam kulit. Asam oleat digunakan karena
memiliki keuntungan yaitu dapat melembutkan dan melembabkan kulit. Penelitian
ini bertujuan untuk memperoleh formulasi patch transdermal meloksikam yang
memiliki sifat fisik baik sesuai dengan persyaratan dan nilai difusi yang paling tinggi
dengan asam oleat sebagai peningkat penetrasi. Patch dibuat menjadi 4 formula, F1
tanpa peningkat penetrasi, F2 5%, F3 10% dan F4 20%. Patch transdermal dilakukan
uji fisik meliputi uji organoleptis, keseragaman bobot, pH, ketahanan lipat, moisture
content dan ketebalan, serta uji difusi menggunakan sel difusi Franz. Hasil uji sifat
fisik memenuhi persyaratan yang baik. Hasil difusi memiliki nilai tertinggi pada
formula 3 96.38% dan mengikuti kinetika pelepasan Higuchi dengan nilai k tertinggi
pada formula 3. Perbedaan konsentrasi asam oleat tidak mempengaruhi laju difusi
meloksikam dari sediaan patch transdermal (p < 0,05).
Kata kunci: Meloksikam, Asam oleat, Patch transdermal dan difusi.
date: 2021
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   ADAWIYAH, SITI ROBIATUL dan Nining, Nining dan Amalia, Anisa  (2021) PENGARUH PENGGUNAAN ASAM OLEAT SEBAGAI PENINGKAT PENETRASI TERHADAP SIFAT FISIK DAN DIFUSI SEDIAAN PATCH TRANSDERMAL DISPERSI PADAT MELOKSIKAM.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21443/1/FS03-210403.pdf