eprintid: 21222
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/12/22
datestamp: 2023-02-15 03:50:25
lastmod: 2023-02-15 03:50:25
status_changed: 2023-02-15 03:50:25
type: thesis
metadata_visibility: show
creators_name: Iqbal, Muhammad
creators_name: Nining, Nining
creators_name: Nugrahaeni, Fitria
title: OPTIMASI FORMULA ORAL DISSOLVING FILM CETIRIZINE HCl
BERBASIS MALTODEXTRIN-SORGUM SEBAGAI FILM FORMING DAN
POLIETILEN GLIKOL 400 SEBAGAI PLASTICIZER
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Pati adalah salah satu biopolimer yang termasuk alami serta ketersediaannya yang
luas dan dapat digunakan sebagai bahan pembentuk film. Modifikasi pati dapat
digunakan dengan dua cara yaitu menggunakan enzim atau asam sehingga
menghasilkan pati dengan kelarutan yang lebih baik yang dikenal dengan
maltodextrin. Polietilen glikol 400 adalah eksipien yang dapat digunakan sebagai
Plasticizer dalam sediaan Oral Dissolving Film (ODF). Tujuan penelitian ini
adalah untuk mendapatkan formula optimal dari sediaan ODF Cetirizine HCl
berbasis Maltodextrin sebagai film forming dan polietilen glikol 400 sebagai
Plasticizer dengan aplikasi Response Surface Methodology (RSM). Metode yang
digunakan pada penelitian ini menggunakan Response Surface Methodology
(RSM) dengan pola Central Composite Design (CCD) yang menghasilkan 14
formula dengan rentang nilai terhadap konsentrasi film forming dan Plasticizer.
ODF akan dilakukan pengujian terhadap disintegration time, elongasi dan tensile
strenght. Hasil penelitian diperoleh formula optimal pada konsentrasi yang telah
disarankan oleh RSM yaitu Maltodextrin sebesar 4,34% dan polietilen glikol 400
10% dengan respon disintegration time 99,20 sec, tensile strengh 1,26 Mpa dan
elongasi 110,7% serta terdapat nilai desirability sebesar 0,67. Dan juga terdapat
hasil observasi terhadap respon disintegration time 99,7 sec dengan persentase
error sebesar 0,5% , tensile strenght 1,28 Mpa dengan persentase error sebesar
1,59% dan elongasi 101,67% dengan persentase error sebesar 0,03% .
Kesimpulannya adalah semakin tinggi konsentrasi polimer maka meningkatkan
nilai tensile strenght dan menurunkan nilai elongasi dan disintegration time
sedangkan semakin tinggi konsentrasi plasticizer maka meningkatkan nilai
elongasi serta menurunkan tensile strength serta disintegration time
Kata Kunci: Oral Dissolving Film, Maltodextrin-Sorgum, Cetirizine HCl,
Response Surface Methodology.
date: 2021
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Iqbal, Muhammad dan Nining, Nining dan Nugrahaeni, Fitria  (2021) OPTIMASI FORMULA ORAL DISSOLVING FILM CETIRIZINE HCl BERBASIS MALTODEXTRIN-SORGUM SEBAGAI FILM FORMING DAN POLIETILEN GLIKOL 400 SEBAGAI PLASTICIZER.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21222/1/FS03-210320.pdf