eprintid: 21173
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/11/73
datestamp: 2023-02-14 08:23:37
lastmod: 2023-02-14 08:23:37
status_changed: 2023-02-14 08:23:37
type: thesis
metadata_visibility: show
creators_name: Izzati, Hani Nur
creators_name: Rahmi, Hanifah
creators_name: Dwita, Lusi Putri
title: UJI AKTIVITAS ANTIOKSIDAN PADA HATI TIKUS DIABETES
MELITUS TIPE 2 DENGAN PEMBERIAN XILOOLIGOSAKARIDA
BERDASARKAN KADAR MALONDIALDEHID DAN AKTIVITAS
KATALASE
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Diabetes melitus tipe 2 terjadi karena adanya resistensi insulin. Suplemen diet
dengan xilooligosakarida dapat menurunkan gula darah pada penderita diabetes
melitus. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan
xilooligosakarida berdasarkan aktivitas katalase dan kadar MDA pada hati tikus
diabetes melitus tipe 2. Penelitian menggunakan 20 ekor tikus putih jantan yang
dibagi menjadi 5 kelompok, yaitu kelompok normal diberi pakan standar,
kelompok negatif diinduksi streptozotosin dan pakan hiperlipid, 3 kelompok
perlakuan diberi xilooligosakarida bonggol jagung dosis 200 mg/200gBB, 300
mg/200gBB, 400 mg/200gBB selama 67 hari. Perlakuan dilakukan dengan
pembedahan organ hati pada hari ke-67. Pengukuran aktivitas katalase dan kadar
MDA menggunakan spektrofotometer UV-Vis. Data analisis dengan ANOVA
satu arah dan dilanjutkan dengan uji Tukey. Hasil penelitian menunjukkan kadar
MDA dan aktivitas katalase pada ketiga dosis xilooligosakarida menunjukkan
adanya pengaruh berbeda bermakna dengan kelompok negatif, sedangkan untuk
dosis yang paling efektif dalam peningkatan aktivitas katalase dan mencegah
peningkatan kadar MDA yaitu pada kelompok dosis 3 (400 mg/200 gBB).
Penelitian ini menunjukkan bahwa xilooligosakarida mampu sebagai antioksidan
bagi penderita diabetes melitus tipe 2.
Kata Kunci: Xilooligosakarida, Malondialdehyde, Aktivitas Katalase, Diabetes
Melitus.
date: 2020
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Izzati, Hani Nur dan Rahmi, Hanifah dan Dwita, Lusi Putri  (2020) UJI AKTIVITAS ANTIOKSIDAN PADA HATI TIKUS DIABETES MELITUS TIPE 2 DENGAN PEMBERIAN XILOOLIGOSAKARIDA BERDASARKAN KADAR MALONDIALDEHID DAN AKTIVITAS KATALASE.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21173/1/FS03-210109.pdf