eprintid: 21167
rev_number: 10
eprint_status: archive
userid: 3858
dir: disk0/00/02/11/67
datestamp: 2023-02-14 08:23:10
lastmod: 2023-02-14 08:23:10
status_changed: 2023-02-14 08:23:10
type: thesis
metadata_visibility: show
creators_name: Indriani, Vivi
creators_name: Rahmi, Hanifah
creators_name: Dwita, Lusi Putri
title: UJI AKTIVITAS ANTIOKSIDAN TERHADAP KADAR
MALONDIALDEHID DAN KATALASE PADA ADIPOSA TIKUS
DIABETES MELITUS TIPE 2 YANG DIBERI XILOOLIGOSAKARIDA
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Limbah bonggol jagung merupakan sumber xilan tinggi yang dapat dimanfaatkan
sebagai bahan baku untuk produksi Xilooligosakarida (XOS) yang berpotensi
sebagai prebiotik dan memiliki aktivitas antioksidan, antidiabetes dan
antikolesterol. Penurunan sensitifitas di jaringan adiposa terhadap insulin pada
tikus diabetes melitus tipe 2 menyebabkan keadaan hiperglikemia. Penelitian ini
bertujuan untuk mengetahui aktivitas antioksidan terhadap kadar Malondialdehid
(MDA) dan aktivitas katalase pada adiposa tikus diabetes melitus tipe 2. Hewan
uji dibagi 5 kelompok: kelompok normal, kelompok negatif, dan 3 kelompok uji
1,2,3 yang diberikan xilooligosakarida bonggol jagung dengan dosis 200 mg/200
gBB, 300 mg/200gBB dan 400 mg/200 gBB selama 67 hari. Kondisi diabetik
dilakukan dengan pemberian pakan hiperlipid dan induksi streptozotocin (35
mg/kgBB). Pengambilan organ adiposa pada hari ke-67 kemudian dilakukan
pengukuran kadar MDA dan aktivitas katalase menggunakan spektrofotometer
UV-VIS. Pemberian XOS bonggol jagung 400 mg/200 gBB merupakan dosis
optimal dalam uji antioksidan berdasarkan penurunan kadar Malondialdehid
(MDA) dan peningkatan aktivitas katalase pada adiposa tikus diabetes melitus
tipe 2.
Kata Kunci: Diabetes Melitus Tipe 2, Xilooligosakarida, Malondialdehid,
Katalase
date: 2020
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Indriani, Vivi dan Rahmi, Hanifah dan Dwita, Lusi Putri  (2020) UJI AKTIVITAS ANTIOKSIDAN TERHADAP KADAR MALONDIALDEHID DAN KATALASE PADA ADIPOSA TIKUS DIABETES MELITUS TIPE 2 YANG DIBERI XILOOLIGOSAKARIDA.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21167/1/FS03-210105.pdf