eprintid: 21049
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/10/49
datestamp: 2023-02-13 08:09:49
lastmod: 2023-02-13 08:09:49
status_changed: 2023-02-13 08:09:49
type: thesis
metadata_visibility: show
creators_name: Rahmatullah, Rizki
creators_name: Nining, Nining
creators_name: Amalia, Anisa
title: OPTIMASI FORMULA ORAL DISSOLVING FILM CETIRIZINE HCL
BERBASIS MALTODEXTRIN-SORGUM SEBAGAI FILM FORMING
DAN TRIETIL SITRAT SEBAGAI PLASTICIZER
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Pati merupakan biopolimer alami yang digunakan sebagai bahan pembentuk film
dan trietil sitrat dapat berperan sebagai plasticizer dalam sediaan oral dissolving
film (ODF). Kelarutan pati dapat ditingkatkan dengan melakukan modifikasi pati
menggunakan enzim atau asam menjadi maltodextrin dengan sifat kelarutan yang
lebih baik. Cetirizin HCl digunakan sebagai obat anti alergi dengan dosis dewasa
rendah sebesar 10mg/hari dengan sediaan yang banyak tersedia berupa tablet dan
kapsul, sediaan ini sulit dikonsumsi pada pasien pediatrik, geriatrik maupun
pasien dengan kesulitan menelan sehingga diperlukan sediaan alternatif yaitu
ODF agar pasien tersebut dapat mengkonsumsi obat ini dengan mudah. Tujuan
penelitian ini adalah untuk mendapatkan formula optimal dari sediaan ODF
cetirizine HCl berbasis Maltodextrin-Sorgum sebagai film forming dan trietil sitrat
sebagai plasticizer dengan aplikasi RSM. Modifikasi pati dilakukan menggunakan
metode enzimatis dengan enzim alfa-amilase kemudian dilakukan karakterisasi
maltodextrin-sorgum dengan hasil uji dextrose ekuvalen sebesar 6, swelling power
sebesar 2,87, solubility sebesar 52,9% dan yield value sebesar 86,71%. Sediaan
ODF dibuat menjadi 14 formula dengan rentang nilai terhadap konsesntrasi
polimer sebesar 2,59 - 6% dan plasticizer sebesar 3 – 10% yang telah ditentukan
oleh Response Surface Methodology (RSM) dengan pola Central Composite
Design (CCD). Hasil penelitian diperoleh formula optimal pada konsentrasi yang
telah disarankan oleh RSM yaitu Maltodextrin-Sorgum sebesar 4,56% dan trietil
sitrat 10% dengan respon disintegration time 75,67 sec, elongasi 108,85%, dan
tensile strengh 1,39 Mpa sehingga film yang dihasilkan memenuhi syarat oral
dissolving film yang baik
Kata Kunci: Oral Dissolving Film, Maltodextrin-Sorgum, Trietil Sitrat,
Response Surface Methodology (RSM), Cetirizine HCl
date: 2021
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Rahmatullah, Rizki dan Nining, Nining dan Amalia, Anisa  (2021) OPTIMASI FORMULA ORAL DISSOLVING FILM CETIRIZINE HCL BERBASIS MALTODEXTRIN-SORGUM SEBAGAI FILM FORMING DAN TRIETIL SITRAT SEBAGAI PLASTICIZER.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/21049/1/FS03-210316.pdf