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<http://repository.uhamka.ac.id/id/eprint/20701> <http://purl.org/dc/terms/title> "FORMULASI TABLET DARI ENZIM PAPAIN BUAH PEPAYA”"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://repository.uhamka.ac.id/id/eprint/20701> <http://purl.org/ontology/bibo/abstract> "ABSTRAK\r\nEnzim papain dapat membantu sistem pencernaan dan merangsang fungsi kekebalan tubuh, untuk\r\nmempermudah penggunaan enzim papain maka dibuat menjadi sediaan granul. Tujuan dari penelitian\r\nini adalah untuk mengetahui variasi kombinasi Mannitol dan Sorbitol sebagai bahan pengisi pada\r\ngranul enzim papain secara granulasi basah memenuhi syarat secara farmasetika. Penelitian ini dibuat\r\ndalam 5 formula (F) uji dengan perbandingan Mannitol dan Sorbitol sebagai bahan pengisi yang terdiri\r\ndari F1 (Mannitol 100% : Sorbitol 0%), F2 (Mannitol 75% : Sorbitol 25%), F3 (Mannitol 50% : Sorbitol\r\n50%), F4 (Mannitol 25% : Sorbitol 75%), dan F5 (Mannitol 0% : Sorbitol 100%). Granul dilakukan\r\nevaluasi meliputi waktu alir, sudut diam, dan kompresibilitas. Hasil evaluasi granul F1-F5 dari waktu\r\nalir (5,73 detik-3,96 detik), dari sudut diam (29,9545o\r\n-27,3901o\r\n), dan dari kompresibilitas (1,3264%-\r\n3,6585%). Hasil evaluasi granul dianalisa statistik One-Way ANOVA dengan taraf kepercayaan 95%\r\n(α=0,05) dan diperoleh nilai signifikasi <0,05 yang menunjukkan perbedaan bermakna sehingga\r\ndilanjutkan dengan Uji Tukey HSD. Simpulan penelitian ini menunjukkan bahwa semakin menurun\r\nMannitol dan meningkat Sorbitol yang digunakan maka waktu alir granul semakin cepat, sudut diam\r\ngranul yang terbentuk semakin kecil dan kompresibilitas granul semakin meningkat.\r\nKata Kunci: Enzim Papain, Granul, Mannitol, Sorbitol, PVP"^^<http://www.w3.org/2001/XMLSchema#string> .
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