eprintid: 20553
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/02/05/53
datestamp: 2023-02-09 11:11:12
lastmod: 2023-02-09 11:11:12
status_changed: 2023-02-09 11:11:12
type: thesis
metadata_visibility: show
creators_name: Salsabila, Anggi  Fuji
creators_name: Gusmayadi, Inding
creators_name: Sjahid, Landyyun Rahmawan
title: PENGARUH KONSENTRASI PEG-4000 SEBAGAI POLIMER
TERHADAP DISOLUSI KAPSUL INDOMETASIN
MIKROPARTIKEL DAN NANOPARTIKEL
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Indometasin merupakan agen antiinflamasi yang memiliki kelarutan rendah.
Teknik pengecilan ukuran partikel merupakan metode dalam meningkatkan
kelarutan suatu zat. Selain ukuran partikel keberadaan senyawa-senyawa lain
dalam suatu formula sediaan akan berpengaruh juga terhadap kelarutan senyawa
aktif. Penelitian ini bertujuan untuk mengetahui pengaruh ukuran partikel serta
konsentrasi PEG-4000 terhadap disolusi kapsul indometasin. Dibuat 2 ukuran
partikel yang berbeda yaitu mikropartikel dan nanopartikel dengan campuran
PEG-4000 berbeda konsentrasi. Proses pengecilan ukuran partikel indometasin
dilakukan dengan metode wet milling dan dikeringkan dengan metode freezy
drying selanjutnya dilakukan evaluasi ukuran partikel dengan PSA. Serbuk
kemudian diuji sifat alirnya dan dibuat menjadi kapsul, dilakukan evaluasi
meliputi uji keseragaman bobot, waktu hancur, uji disolusi dilanjutkan uji
statistik.. Hasil penelitian serbuk nanopartikel memiliki sifat alir yang bagus, kapsul
indometasin ukuran nanopartikel memiliki waktu untuk hancur lebih cepat
dibandingkan ukuran mikropartikel, seluruh formula kapsul memiliki keseragaman
bobot yang sesuai. Hasil disolusi pada menit ke-20 kapsul indometasin dengan ukuran
mikro secara berurutan menghasilkan disolusi sebesar 80,83%, 83,06% dan 84,24%.
Sedangkan kapsul indometasin ukuran nano menghasilkan disolusi secara berurutan
sebesar 86,15%, 90,12%, dan 94,12%. Hasil analisis data menggunakan ANOVA dua
arah didapat nilai 0,00 (<0,05), maka terdapat perbedaan bermakna antar formula,
yaitu ukuran nano yang memiliki disolusi lebih baik dari mikro serta semakin tinggi
konsentrasi PEG-400 maka disolusi semakin meningkat.
Kata Kunci : freeze dry, kapsul indometasin, PEG-4000, ukuran partikel, wet
milling, %disolusi.
date: 2021
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Salsabila, Anggi Fuji dan Gusmayadi, Inding dan Sjahid, Landyyun Rahmawan  (2021) PENGARUH KONSENTRASI PEG-4000 SEBAGAI POLIMER TERHADAP DISOLUSI KAPSUL INDOMETASIN MIKROPARTIKEL DAN NANOPARTIKEL.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/20553/1/FS03-210226.pdf