eprintid: 19139
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/01/91/39
datestamp: 2023-02-03 04:29:25
lastmod: 2023-02-03 04:29:25
status_changed: 2023-02-03 04:29:25
type: thesis
metadata_visibility: show
creators_name: Oktaviani, Candra Dwi
creators_name: Prastiwi, Rini
creators_name: Sunaryo, Hadi
title: UJI AKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN PEPAYA
JEPANG (Cnidoscolus aconitifolius (Mill.) I.M.Johnst.) DAN EKSTRAK
BUAH PARE (Momordica charantia L.) TERHADAP PENURUNAN KADAR
KOLESTEROL TOTAL DAN LDL PADA TIKUS DENGAN KONDISI
HIPERGLIKEMIA DAN HIPERLIPIDEMIA
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Hiperlipidemia adalah tingginya kadar kolesterol darah, trigliserida, LDL dan
rendahnya kadar HDL. Tanaman herbal seperti daun pepaya jepang dan buah pare
dalam pemakaian tunggal dapat menurunkan kadar kolesterol total dan LDL.
Penelitian ini bertujuan untuk mengetahui aktivitas kombinasi ekstrak etanol 70%
daun pepaya jepang dan buah pare terhadap penurunan kadar kolesterol total dan
LDL pada tikus dengan kondisi hiperglikemia dan hiperlipidemia. Penelitian ini
menggunakan 8 kelompok yaitu normal, negatif, positif (Atorvastatin 0,986 mg/Kg
BB), dosis I (daun pepaya jepang 500 mg/Kg BB), dosis II (buah pare 400 mg/Kg
BB), dosis III (daun pepaya jepang 500 mg/Kg BB + buah pare 200 mg/Kg BB),
dosis IV (daun pepaya jepang 250 mg/Kg BB + buah pare 200 mg/Kg BB), dosis V
(daun pepaya jepang 250 mg/Kg BB + buah pare 400 mg/Kg BB). Data persentase
penurunan kadar kolesterol total dan LDL dianalisis menggunakan uji ANOVA one
way dan dilanjutkan dengan uji Tukey. Hasil penelitian menunjukkan bahwa dosis III
(daun pepaya jepang 500 mg/Kg BB + buah pare 200 mg/Kg BB) memiliki aktivitas
yang sebanding dengan kontrol positif (P ≥ 0,05). Persentase penurunan kadar
kolesterol total dan LDL dosis III sebesar 52,51%; 55,54% dan kontrol positif sebesar
54,13%; 58,49%.
Kata kunci: Cnidoscolus aconitifolius, Momordica charantia, hiperglikemia,
hiperlipidemia, kolesterol total, LDL
date: 2019
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Oktaviani, Candra Dwi dan Prastiwi, Rini dan Sunaryo, Hadi  (2019) UJI AKTIVITAS KOMBINASI EKSTRAK ETANOL DAUN PEPAYA JEPANG (Cnidoscolus aconitifolius (Mill.) I.M.Johnst.) DAN EKSTRAK BUAH PARE (Momordica charantia L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS DENGAN KONDISI HIPERGLIKEMIA DAN HIPERLIPIDEMIA.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/19139/1/S03-200115.pdf