eprintid: 18873
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/01/88/73
datestamp: 2023-02-01 09:42:43
lastmod: 2023-02-01 09:42:43
status_changed: 2023-02-01 09:42:43
type: thesis
metadata_visibility: show
creators_name: zikriah, Ririh
creators_name: Hariyanti, Hariyanti
creators_name: Rachmania, Rizky Arcinthya
title: MOLECULAR DOCKING SENYAWA ALKALOID HERBA
BAKUNG PUTIH (Crinum asiaticum L.) TERHADAP RESEPTOR
SIKLOOKSIGENASE-1 (COX-1) SEBAGAI ANTI INFLAMASI
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Senyawa-senyawa alkaloid yang terdapat dalam herba bakung putih (Crinum
asiaticum L.) memiliki aktivitas sebagai anti inflmasi. Tujuan penelitian ini adalah
untuk mengetahui delapan senyawa alkaloid aktif herba bakung putih (Crinum
asiaticum L.) yaitu criasbetain, galanthidin, hippadin, kalbretorin, licobetain,
lycorisid, prastorimin dan prastorisin untuk digunakan sebagai anti inflamasi
dengan cara menghambat enzim siklooksigenase-1. Metode docking molecular
dilakukan menggunakan software PLANTS, Preparasi ligan dan protein
menggunakan software YASARA dan Marvin Sketch. Hasil molecular docking
dianalisis berdasarkan skor CHEMPLP dimana penurunan skor menunjukan
kestabilan konformasi dengan protein. Senyawa herba bakung putih yang
memperoleh skor CHEMPLP terbaik yaitu hippadine -83,3684 Kkal/mol pada
konformasi 3 serta pembanding aspirin -67,3292 Kkal/mol dan paracetamol -
66,3535 Kkal/mol. Jarak ikatan terbaik pada senyawa hippadine residu asam
amino yang terlibat tyr385 dan his380. Simpulan berdasarkan hasil molecular
docking senyawa herba bakung putih (Crinum asiaticum L.) membuktikan bahwa
senyawa hipadin dan pratorimin berpotensi sebagai senyawa anti inflamasi.
Kata kunci: alkaloid, Crinum asiaticum L., molecular docking, COX-1.
date: 2018
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   zikriah, Ririh dan Hariyanti, Hariyanti dan Rachmania, Rizky Arcinthya  (2018) MOLECULAR DOCKING SENYAWA ALKALOID HERBA BAKUNG PUTIH (Crinum asiaticum L.) TERHADAP RESEPTOR SIKLOOKSIGENASE-1 (COX-1) SEBAGAI ANTI INFLAMASI.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/18873/1/S03-200226.pdf