eprintid: 18843
rev_number: 14
eprint_status: archive
userid: 3858
dir: disk0/00/01/88/43
datestamp: 2023-02-01 09:42:50
lastmod: 2023-02-01 09:42:50
status_changed: 2023-02-01 09:42:50
type: thesis
metadata_visibility: show
creators_name: Lidia Putri, Rizki
creators_name: Hariyanti, Hariyanti
creators_name: Rachmania, Rizky Arcinthya
title: SIMULASI PENAMBATAN MOLEKUL DAN DINAMIKA MOLEKUL
SENYAWA PADA DAUN SALAM (Syzygium polyanthum) SEBAGAI
ANTIINFLAMASI TERHADAP ENZIM SIKLOOKSIGENASE-2
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Daun salam sering dipercaya masyarakat dapat digunakan sebagai terapi
hipertensi, diabetes, asam urat, diare, hiperlipidemia dan antiinflamasi. Penelitian
ini bertujuan untuk menguji efektivitas senyawa pada daun salam terhadap enzim
siklooksigenase-2 sebagai antiinflamasi dan untuk menganalisis stabilitasnya
dengan dinamika molekul. Penambatan molekul dilakukan dengan aplikasi
PLANTS dan dinamika molekular dengan aplikasi GROMACS. Senyawa αHumulene menghasilkan skor ChemPLP –20 kkal/mol berdasarkan metode
penambatan molekul, senyawa tesebut mengasilkan interaksi dan jarak yang baik,
toksisitas senyawa α-Humulene termasuk kedalam kelas V dan celecoxib kelas IV
sehingga tingkat toksisitasnya lebih rendah dibandingkan dengan celecoxib.
Stabilitas senyawa α-Humulene yang diuji melalui dinamika molekular berdasarkan
parameter RMSD, RMSF, energi potensial, ikatan hidrogen dan MMPBSA
memiliki stabilitasnya tidak baik jika dibandingkan dengan celecoxib. Senyawa
pada daun salam yang memiliki aktifitas antiinflamasi yaitu α-Humulene tetapi
tidak stabil jika dibandingkan dengan celecoxib.
Kata Kunci: Daun salam, penambatan molekul, dinamika molekul.
date: 2020
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Lidia Putri, Rizki dan Hariyanti, Hariyanti dan Rachmania, Rizky Arcinthya  (2020) SIMULASI PENAMBATAN MOLEKUL DAN DINAMIKA MOLEKUL SENYAWA PADA DAUN SALAM (Syzygium polyanthum) SEBAGAI ANTIINFLAMASI TERHADAP ENZIM SIKLOOKSIGENASE-2.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/18843/1/S03-200218.pdf