eprintid: 18841
rev_number: 8
eprint_status: archive
userid: 3858
dir: disk0/00/01/88/41
datestamp: 2023-02-01 09:43:14
lastmod: 2023-02-01 09:43:14
status_changed: 2023-02-01 09:43:14
type: thesis
metadata_visibility: show
creators_name: Awalunnisa, Siti
creators_name: Hariyanti, Hariyanti
creators_name: Rachmania, Rizky Arcinthya
title: SIMULASI PENAMBATAN MOLEKUL DAN DINAMIKA MOLEKUL
SENYAWA PADA DAUN SALAM (Syzygium polyanthum) TERHADAP
RESEPTOR ESTROGEN-α SEBAGAI ANTIKANKER PAYUDARA
ispublished: pub
subjects: R
subjects: RS
divisions: 48201
abstract: Kanker payudara merupakan kanker yang paling banyak diderita oleh
wanita dengan jumlah 1,67 juta kasus baru di dunia pada tahun 2012 dengan tingkat
kematian 12,9%. Daun salam diketahui memiliki potensi sebagai antikanker
payudara dengan memiliki IC50 sebesar 2117,77 µg/ml. Penelitian ini bertujuan
untuk menguji efektivitas senyawa pada daun salam terhadap reseptor estrogen-α
sebagai antikanker payudara. Metode yang digunakan dalam penelitian ini adalah
penambatan molekul dan dinamika molekul menggunakan struktur reseptor
estrogen-α dengan kode PDB 3ERT, dan pembanding tamoksifen. Setelah
dilakukan simulasi penambatan molekul, alfa-humulen memiliki binding affinity
sebesar -8,5 kkal/mol, sedangkan tamoksifen memiliki nilai sebesar -7,8 kkal/mol.
Alfa-humulen memenuhi analisis aturan Lipinski’s Rule of Five, dan toksisitasnya
berada pada kelas V. Nilai RMSD dan RMSF alfa-humulen pada dinamika molekul
menunjukkan ketidakstabilan, sedangkan energi potensial stabil, dan hasil MMPBSA untuk binding energy alfa-humulen tidak terbentuk. Berdasarkan hasil di
atas, dapat disimpulkan bahwa alfa-humulen tidak stabil terhadap reseptor
estrogen-α sebagai antikanker payudara.
Kata Kunci: Daun salam, penambatan molekul, dinamika molekul, reseptor
estrogen-α.
date: 2020
date_type: completed
full_text_status: public
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Awalunnisa, Siti dan Hariyanti, Hariyanti dan Rachmania, Rizky Arcinthya  (2020) SIMULASI PENAMBATAN MOLEKUL DAN DINAMIKA MOLEKUL SENYAWA PADA DAUN SALAM (Syzygium polyanthum) TERHADAP RESEPTOR ESTROGEN-α SEBAGAI ANTIKANKER PAYUDARA.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/18841/1/S03-200217.pdf