%0 Journal Article
%@ 0378-5173
%A Gusmayadi, Inding
%A Mulya Lestari, Pramulani
%D 2019
%F repository:1657
%I Elshivier
%J International Journal of Pharmaceutics
%T VARIATION CONCENTRATION OF CITRIC ACID AS ACID  SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP  MANGOSTEEN (Garcinia mangostana L) EXTRACTS EFFERVESCENT  TABLET
%U http://repository.uhamka.ac.id/id/eprint/1657/
%X Aim: Citric acid is an acid source in effervescent tablet which reacts rapidly with solvent. It  can increase dissolving time. In this research, extract was made into effervescent tablet. The  research aimed at knowing increased concentration of citric acid as acid source can improve  the physical characteristic of effervescent tablet.  Methods: Pericarp mangosteen macerated by water as solvent, and the extract was made into  powder by spray dryer method. Dry extract was made into 5 formulas effervescent tablet with  the different concentrations of citric acid, 15%, 20%, 25%, 30% and 35% as acid sources. The  evaluation of tablets quality included organoleptic evaluation, weight uniformity, size  uniformity, hardness, friability, and dissolving times.  Results: The result of dissolving time was subquently 10.50±0.57, 4.52±1.04, 3.32±0.13,  3.13±0.14, and 3.42±0.14 minutes. The value of dissolving time between the concentration of  citric acid were significanly different (ANOVA, p<0,05).  Conclusion: It can be concluded that the level of concentration of citric acid affected on  dissolving time of the pericarp mangosteen   (Garcinia mangostana L.) dry extract effervescent  tablets.    Keywords: Mangosteen, Effervescent tablet, Citric acid