eprintid: 13937
rev_number: 10
eprint_status: archive
userid: 2319
dir: disk0/00/01/39/37
datestamp: 2022-08-22 11:58:18
lastmod: 2022-08-22 11:58:18
status_changed: 2022-08-22 11:58:18
type: thesis
metadata_visibility: show
creators_name: Prasadhana, Farras
creators_name: Naniek Setiadi, Rajab
creators_name: Inding, Gusmayadi
creators_id: indinggusmayadi@uhamka.ac.id
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0003-4756-8376
title: Penggunaan Pati Labu Kuning (Cucurbita Moschata Durch.) Terpragelatinisasi Sebagai Superdisintegran Pada Fast Disintegrating Tablets Metoklopramid Hidroklorida
ispublished: pub
subjects: RS
divisions: 48201
abstract: Metoklopramid HCl berkhasiat sebagai antiemetik yang membutuhkan efek cepat,
sehingga sangat efektif dibuat dalam fast disintegrating tablet. Penelitian ini
menggunakan pati labu kuning terpragelatinisasi sebagai superdisintegran. Tujuan
penelitian ini untuk mengetahui apakah pati labu kuning terpragelatinisasi dapat
dijadikan sebagai superdisintegran dalam formulasi fast disintegrating tablet.
Superdisintegran dibuat menjadi 5 konsentrasi berbeda dalam 5 formula yaitu 6%,
7%, 8%, 9% dan 10% dengan metode kempa langsung. Uji yang dilakukan
meliputi kekerasan, keregasan, keseragaman ukuran, keseragaman bobot, waktu
hancur termodifikasi dan evaluasi kimia tablet. Hasil evaluasi uji kekerasan yaitu
F1:1,79 Kg/cm2, F2:2,05 Kg/cm2, F3:2,14 Kg/cm2, F4:2,41 Kg/cm2 dan F5:2,74
Kg/cm2. Hasil evaluasi uji keregasan yaitu F1:1,97%, F2:1,30%, F3:0,93%,
F4:0,88% dan F5:0,57%. Hasil evaluasi uji waktu hancur yang diperoleh yaitu
F1:29,01 detik, F2:25,87 detik, F3:22,89 detik, F4:20,76 detik dan F5:19,48 detik.
Hasil analisa statistik ANOVA satu arah menunjukkan adanya perbedaan
bermakna. Dapat disimpulkan bahwa pati labu kuning terpragelatinisasi dapat
dijadikan superdisintegran dalam formulasi fast disintegrating tablet
metoklopramid HCl dan menghasilkan sifat fisik yang memenuhi persyaratan.

Kata kunci : Labu kuning, pati labu kuning, pragelatinisasi, superdisintegrant,
fast disintegrating tablets.
date: 2022-04-15
date_type: completed
full_text_status: restricted
institution: Universitas Muhammadiyah  Dr  Hamka
department: Fakultas Farmasi Dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Prasadhana, Farras dan Naniek Setiadi, Rajab dan Inding, Gusmayadi  (2022) Penggunaan Pati Labu Kuning (Cucurbita Moschata Durch.) Terpragelatinisasi Sebagai Superdisintegran Pada Fast Disintegrating Tablets Metoklopramid Hidroklorida.  Bachelor thesis, Universitas Muhammadiyah Dr Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/13937/1/FFS_FARMASI_S03-190140_FARRAS%20PRASADHANA.pdf