eprintid: 13936
rev_number: 8
eprint_status: archive
userid: 2319
dir: disk0/00/01/39/36
datestamp: 2022-08-22 11:58:15
lastmod: 2022-08-22 11:58:15
status_changed: 2022-08-22 11:58:15
type: thesis
metadata_visibility: show
creators_name: Febriat, Ayui Elsa
creators_name: Hariyanti, Hariyanti
creators_name: Rizky Arcinthya Rachmania, Rizky
creators_id: hariyanti@uhamka.ac.id
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0001-7236-563X
creators_orcid: 0000-0002-9233-1557
title: Molecular Docking Kandungan Senyawa Flavonoid Daun Sendok (Plantago Major L.) Terhadap Enzim Xantin Oksidase Sebagai Anti Hiperurisemia
ispublished: pub
subjects: RS
divisions: 48201
abstract: Asam urat merupakan hasil metabolisme akhir dari purin yaitu salah satu
komponen asam nukleat yang terdapat dalam inti sel tubuh. Daun sendok
(Plantago major L.) merupakan salah satu tanaman herbal yang memiliki aktivitas
antihiperurisemia, karena mampu berikatan dan menghambat reseptor xantin
oksidase sehingga dapat menurunkan kadar asam urat di dalam darah dan
memiliki kandungan senyawa flavonoid: apigenin-7-glucosid, baicalein,
hispidulin, hispidulin-7-glucuronide, homoplantaginin, luteolin-7-glucosid,
luteolin-7-diglucosid, luteolin 6-hydroxy-4’methoxy-7-galactoside, nepetin 7-
glucoside, plantaginin, scutellarein. Penelitian ini bertujuan untuk mencari
kandungan senyawa flavonoid terbaik dari daun sendok yang memiliki skor
ChemPLP lebih besar daripada ligan pembanding (Allopurinol) dan memenuhi
aturan Lipinski’s Rule of Five sehingga dapat dijadikan kandidat obat
antihiperurisemia. Aplikasi yang digunakan yaitu ChemDraw Professional,
MarvinSketch, YASARA, PLANTS, serta Discovery Studio. Scutellarein
memiliki skor yang paling besar -99,0641 kkal/mol dibandingkan dengan
allopurinol yang memiliki nilai skor ChemPLP -98,8155 kkal/mol dan memenuhi
aturan Lipinski’s Rule of Five. Maka dapat disimpulkan bahwa senyawa
scutellarein dapat berpotensi sebagai antihiperurisemia.

Kata kunci: Plantago major L., molecular docking, hiperurisemia.
date: 2022-04-15
date_type: completed
full_text_status: restricted
institution: Universitas Muhammadiyah  Dr  Hamka
department: Fakultas Farmasi Dan Sains
thesis_type: bachelor
thesis_name: bphil
referencetext: Agarwal S, Chadha D, Mehrotra R. (2015). Molecular Modeling and
Spectroscopic Studies of Semustine Binding with DNA and Its Comparison
with Lomustine-DNA Adduct Formation. Journal of Biomolecular Structure
and Dynamics. 33(8) : 1653–1668.
Alpiansyah A. (2015). Antihyperuricemia Potential of Sida rhombifolia L. As A
Treatment for Gout. Artikel Review. Journal Majority. 4(3) : 9–13.
Arwansyah, Hasrianti. (2014). Simulasi Molecular Docking Senyawa Kurkumin
dan Analognya sebagai Selective Androgen Receptor Modulators ( SARMs )
pada Kanker Prostat. Jurnal Dinamika. 05(2) : 60–75.
Dianati NA. (2015). Gout and Hiperurisemia. Article Review. Journal Majority.
4(3) : 82–89.
Diantari E, Candra A. (2013). Pengaruh Asupan Purin dan Cairan Terhadap Kadar
Asam Urat Wanita Usia 50-60 Tahun di Kecamatan Gajah Mungkur,
Semarang. Journal of Nutrition College. 2(1) : 44–49.
Friesner RA, Murphy RB, Repasky MP, Frye LL, Greenwood JR, Halgren TA,
Sanschagrin PC, Mainz DT. (2006). Extra Precision Glide: Docking and
Scoring Incorporating A Model of Hydrophobic Enclosure for Protein-
Ligand Complexes. Journal of Medicinal Chemistry. 49(21) : 6177–6196.
Fukunari A, Okamoto K, Nishino T, Eger BT, Pai EF, Kamezawa M, Yamada I,
Kato N. (2004). Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-
1Hpyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor
with Hepatic Excretion. The Journal of Pharmacology and Experimental
Therapeutics. 311(2) : 519-528.
Jin M, Yang F, Yang I,Yin Y, Luo JJ, Wang H, Yang XF. (2012). Uric Acid,
Hyperuricemia and Vascular Diseases. Frontiers in Bioscience. 17(1) : 656–
669.
Kato S, Ando M, Mizukoshi T, Nagata T, Katsuno T, Kosugi T, Tsuboi N,
Maruyama S. (2016). Randomized Control Trial for the Assessment of the
Anti-Albuminuric Effects of Topiroxostat in Hyperuricemic Patients with
Diabetic Nephropathy. Nagoya Journal of Medical Science. 78(2) : 135-142.
Korb O, Stutzle T, Exner TE. (2009). Empirical Scoring Functions for Advanced
Protein-Ligand Docking with PLANTS. Journal of Chemical Information
and Modeling. 49(1) : 84–96.
Kusuma AM, Wahyuningrum R, Widyati T. (2014). Aktivitas Antihiperurisemia
Ekstrak Etanol Herba Pegagan pada Mencit Jantan dengan Induksi Kafein.
Pharmacy. 11(01) : 62–74.

Kuo CF, Grainge MJ, Zhang W, Doherty M. (2015). Global Epidemiology of
Gout Prevalence, Incidence and Risk Factors. Journal Nature Rheumatology.
11 : 649-662.
Lipinski CA. (2000). Drug-Like Properties and The Causes of Poor Solubility and
Poor Permeability. Journal of Pharmacological and Toxicological Methods.
44(2000) : 235–249.
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. (2001). Experimental and
Computational Approaches to Estimate Solubility and Permeability In Drug
Discovery and Development Settings. Drug Discovery Today: Technologies.
46 : 3-26.
Manna A, Laksitorini MD, Hudiyanti D, Siahaan P. (2017). Molecular Docking of
Interaction between E-Cadherin Protein and Conformational Structure of
Cyclic Peptide ADTC3 (Ac-CADTPC-NH2) Simulated On 20 ns. Jurnal
Kimia Sains Dan Aplikasi. 20(1) : 30–36.
Marcou G, Rognan D. (2007). Optimizing Fragment and Scaffold Docking by Use
of Molecular Interaction Fingerprints. Journal of Chemical Information and
Modeling. 47(1) : 195–207.
Muchid A. (2006). Pharmaceutical Care Untuk Pasien Penyakit Arthritis Rematik
. Departemen Kesehatan. Jakarta : 54-82.
Mukesh B, Rakesh K. (2011). Molecular Docking : A Review. International
Journal of Research in Ayurveda and Pharmacy. 2(6) : 1746–1751.
Murray RK, Granner DK, Rodwell VW. (2006). Biokimia Harper. (27th).
Terjemahan : Wulandari N, Rendy L, Dwijayanthi L, Liena, Dany F,
Rachman LY. EGC. Jakarta : 102
Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil PA.
(2014). Biokimia Harper. (29th). Terjemahan : Soeharsono R, Sandra F, Ong
HO. Penerbit Buku Kedokteran EGC. Jakarta : 62
Pebriana RB, Romadhon AF, Yunianto A, Rokhman MR, Fitriyah NQ, Jenie RI,
Meiyanto E. (2012). Docking Kurkumin dan Senyawa Analognya pada
Reseptor Progesteron: Studi Interaksinya sebagai Selective Progesterone
Receptor Modulators (Sprms). Pharmacon. 13(2) : 55-60.
Pietta PG. (2000). Flavonoids As Antioxidants. Review Journal of Natural
Products. 63(7) : 1035–1042.
Purnomo H. (2013). Kimia Komputasi Untuk Farmasi dan Ilmu Terkait: Uji In
Siliko Senyawa Antikanker. Pustaka Pelajar. Yogyakarta : 76-141

Purwanto, Hardjono S. (2016). Hubungan Struktur, Ikatan Kimia dan Aktivitas
Biologis Obat. Dalam : Siswandono (ed). Kimia Medisinal edisi kedua.
Airlangga University Press. Surabaya : 227-244
Rahman A, Hoque MM, Khan MAK, Sarwar MG, Halim MA. (2016). Non-
Covalent Interactions Involving Halogenated Derivatives of Capecitabine
and Thymidylate Synthase : A Computational Approach. Journal Springer
Plus. 5(146) : 1-18.
Samuelsen AB. (2000). The Traditional Uses, Chemical Constituents and
Biological Activities of Plantago major L. A Review. Journal of
Ethnopharmacology. 71(1–2) : 1–21.
Sukarmin. (2015). Faktor- Faktor yang Berhubungan dengan Kadar Asam Urat
dalam Darah Pasien Gout. The University Research Coloquium. 2nd : 95–
100.
Syahputra G. (2015). Peran Bioinformatika dalam Desain Kandidat Molekul Obat.
Bio Trends. 1(1) : 26–27.
Syamsuhidayat SS, Hutapea JR. (1991). Inventaris Tanaman Obat Indonesia I.
Departemen Kesehatan Republik Indonesia. Jakarta.
Trott O, Olson AJ. (2010). AutoDock Vina: Improving the Speed and Accuracy of
Docking with A New Scoring Function, Efficient Optimization and
Multithreading. Journal of Computational Chemistry. 31(2) : 455–461.
Yumita A, Suganda AG, Sukandar EY. (2013). Xanthine Oxidase Inhibitory
Activity of Some Indonesian Medicinal Plants and Active Fraction of
Selected Plants. International Journal of Pharmacy and Pharmaceutical
Sciences. 5(2) : 293–296.
Wells BG, Dipiro JT, Schwinghammer TL, Dipiro CV. (2015). Pharmacotherapy
Handbook (Ninth Edition). Mc Graw-Hill Companies. New York : 1-8.
Zhu Y, Pandya BJ, Choi HK. (2011). Prevalence of Gout and Hyperuricemia In
the US General Population: The National Health and Nutrition Examination
Survey 2007-2008. Arthritis and Rheumatism. 63(10) : 3136–3141.
citation:   Febriat, Ayui Elsa dan Hariyanti, Hariyanti dan Rizky Arcinthya Rachmania, Rizky  (2022) Molecular Docking Kandungan Senyawa Flavonoid Daun Sendok (Plantago Major L.) Terhadap Enzim Xantin Oksidase Sebagai Anti Hiperurisemia.  Bachelor thesis, Universitas Muhammadiyah Dr Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/13936/1/FFS_FARMASI_S03-190139_ELSA%20AYU%20FEBRIATI.pdf