eprintid: 13933
rev_number: 8
eprint_status: archive
userid: 2319
dir: disk0/00/01/39/33
datestamp: 2022-08-22 11:58:06
lastmod: 2022-08-22 11:58:06
status_changed: 2022-08-22 11:58:06
type: thesis
metadata_visibility: show
creators_name: Amalia, Husnul Aulia
creators_name: Priyo Wahyudi, Priyo
creators_name: Elly Wardani, Elly
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
title: Potensi Antibiofilm Streptococcus Mutans Dari Subfraksi Etil Asetat Daun Temu Putih (Curcuma Zedoaria (Christm.) Roscoe)
ispublished: pub
subjects: RS
divisions: 48201
abstract: Daun temu putih memiliki potensi sebagai antibiofilm terhadap Streptococcus mutans. Daun temu putih memiliki kandungan senyawa flaonoid dan tanin yang dapat menghambat pembentukan biofilm dengan cara menghambat agregasi bakteri. Penelitian ini bertujuan untuk mengetahui potensi antibiofilm Streptococcus mutans dari subfraksi etil asetat daun asetat, dan metanol, kemudian dielusi menggunakan kromatografi kolom dengan metode step gradient polarity (SGP) menggunakan pelarut n-heksan-etil asetat dan etil asetat-metanol. Hasil subfraksi, kemudian dianalisis menggunakan kromatografi lapis tipis dan dikelompokkan berdasarkan rentang Rf yang mendekati. Kelompok subfraksi yang diperoleh dilakukan uji potensi antibiofilm dengan metode mikrodilusi, kemudian dianalisis dengan menggunakan regresi linear untuk memperoleh nilai IC50 dan potensi relatif. Hasil penelitian menunjukkan subfraksi etil asetat daun temu putih yang memiliki yang memiliki potensi antibiofilm Streptococcus mutans yaitu subfraksi etil asetat Rf 2 (0,71-0,68) dengan nilai IC50 88,85 μg/ml dan potensi relatif sebesar 15,54 kali klorheksidin glukonat.

Kata kunci: Daun Temu Putih, Subfraksi Etil Asetat, Antibiofilm, Streptococcus mutans.
date: 2022-04-15
date_type: completed
full_text_status: restricted
institution: Universitas Muhammadiyah  Dr  Hamka
department: Fakultas Farmasi Dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Amalia, Husnul Aulia dan Priyo Wahyudi, Priyo dan Elly Wardani, Elly  (2022) Potensi Antibiofilm Streptococcus Mutans Dari Subfraksi Etil Asetat Daun Temu Putih (Curcuma Zedoaria (Christm.) Roscoe).  Bachelor thesis, Universitas Muhammadiyah Dr Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/13933/1/FFS_FARMASI_S03-190135_AULIA%20HUSNUL%20AMALIA.pdf