eprintid: 13861
rev_number: 8
eprint_status: archive
userid: 2319
dir: disk0/00/01/38/61
datestamp: 2022-09-15 06:00:07
lastmod: 2022-09-15 06:00:07
status_changed: 2022-09-15 06:00:07
type: thesis
metadata_visibility: show
creators_name: Anwar, Amalia
creators_name: Yudi, Srifiana
creators_name: Anisa Amalia, Anisa
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
title: Pengaruh Penggunaan Kombinasi Tween 60 Dan Span 60 Terhadap Laju Difusi Transethosome Kurkumin
ispublished: pub
subjects: RS
divisions: 48201
abstract: Kurkumin memiliki kelemahan, yaitu sukar larut dalam air, dan absorbsi yang buruk. Sehingga perlu modifikasi teknologi salah satunya adalah transethosome dengan penggunaan perbandingan kombinasi tween 60 dan span 60. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi tween 60 dan span 60 terhadap laju difusi kurkumin secara in vitro menggunakan Sel Difusi. Sistem transethosome dibuat menjadi 4 formula dengan masing-masing perbandingan konsentrasi tween 60 dan span 60 0:1 (F1); 1:1 (F2); 1:2 (F3); dan 2:1 (F4) dengan menggunakan metode dingin. Hasil penelitian yang diperoleh pada parameter ukuran partikel adalah 167,9 ± 4,7 nm – 396 ± 3,7 nm; hasil zeta potensial (-)49,54 ± 1,77 mV – (-)59,05 ± 0,95 mV; nilai indeks 0,000 – 0,571; efisiensi penjerapan 83,76% – 93,75%; dan hasil tiap formula diuji difusi secara in vitro menggunakan Sel Difusi menunjukkan jumlah kumulatif kurkumin masing-masing 300,65 ± 2,79 μg; 584,33 ± 4,28 μg; 418,83 ± 8,7 μg; 1293,45 ± 0,21 μg, dengan kinetika laju difusi mengikuti model higuchi, orde nol, higuchi, dan Korsmeyer-Peppas. Kesimpulan yang didapat menunjukkan bahwa perbandingan kombinasi tween 60 dan span 60 dapat meningkatkan laju difusi transethosome kurkumin.

Kata Kunci : Transethosome, Kurkumin, Tween 60, Span 60, laju difusi
date: 2022-04-10
date_type: completed
full_text_status: restricted
institution: Universitas Muhammadiyah  Dr  Hamka
department: Fakultas Farmasi Dan Sains
thesis_type: bachelor
thesis_name: bphil
referencetext: Aggarwal BB, Sung B. 2008. Pharmacological basis for the role of curcumin in chronic diseases: An age old spice with modern targets, Dalam: Trends in Pharmacological Sciences. Hlm. 85-94.
Agoes G. 2012. Pengembangan Sediaan Farmasi. Seri I. Penerbit ITB. Bandung. Hlm 33-39.
Anand P, Kunnumakkara AB, Newman RA, Anggarwal BB. 2007. Bioavailability of Curcumin: Problems and Promises. Dalam: Molecular Pharmaceutics. Hlm. 807-818
Annajiah W. 2015. Evaluasi profil disolusi sediaan lepas lambat diltiazem hidroklorida yang beredar di pasaran. Skripsi. FKIK. Universitas Islam Negeri Syarif Hidayatullah.
Anonim. 2015. Analysis Software & Reference Kit.
Ansel H.2005. Pengantar Bentuk Sediaan Farmasi. Ed IV. Terjemahan: Farida Ibrahim. UI Press. Jakarta. Hlm 492-493
Ascenso A, Sara R, Catia B, Pedro C, Tiago M, Fabíola GP, Maria VLBB, Sandra S. 2015. Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes. Dalam: International Journal of Nanomedicine. Hlm 5838-5840.
Departemen Kesehatan RI. 1995. Farmakope Indomesia IV. Jakarta. Hlm 751
Ibrahim MA, Yusrida D, Nurzalina AKK, Reem AA, Arshad A.K. 2016. Ethosomal nanocarriers the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. Dalam: International Journal of Nanomedicine. Hlm 2281-2288.
Jacob L, Anoor KP. 2013. A review on usrfactans as edge activators in ultradeformable vesicles for enhanced skin delivery. Dalam: International Journal of Pharma and Bio Sciences. Hlm 340.

Koester LS, Ortega GG, Mayorga P, Bassani VL. 2004. Mathematical evaluation of in vitro release profiles of hydroxypropylmethylcellulose matrix tablets containing carbamazepine associated to beta-cyclodextrin. Dalam: Europen Journal of Pharmaceutics and Biophrmceutics Vol 58. Hlm. 177-179
Lanimarta Y. 2012. Pembuatan dan Uji Penetrasi Nanopartikel Kurkumin – Dendrimer Poliamidoamin (PAMAM) Generasi 4 dalam Sediaan Gel dengan Menggunakan Sel Difusi Franz. Skripsi. FMIPA Universitas Indonesia.
Latheeshjlal L, Phanite JP, Sounjaya Y, Swapna U, Sarika V, Moulika G. 2011. Transdermal Drug delivery system: An Overview. Dalam: International Journal of PharmTech Research Vol. 3. Hlm. 2140-2148.
Lokhandwala H, Deshpande A, Deshpande S. 2013. Kinetic Modeling and Dissolution Profiles Comparison: An Overview. Dalam: International Journal of Pharma and Bio Sciences. Hlm. 729 – 732.
Lv G, Wang F, Cai W, Zhang X. 2014. Characterization of the addition of lipophilic span 80 to the hydrophilic tween 80-stabilized emulsions. Dalam: Colloids Surf A Physicochem. Hlm. 8-13.
Maheswandi RK, Singh AK, Gaddipati J, Srimal RC. 2006, Multiple Biological Activities of Curcumin: a Short Review. Dalam: International Journal of Pharmacy Life Sciences. 2081-2087
Martınez A, Arana P, Fernandez A, Olmo R, Teijon C, Blanco MD. 2013, Synthesis and Characterisation of Alginate/Chitosan Nanoparticles as Tamoxifen Controlled Delivery Systems, Dalam: Journal of Microencapsulation. Hlm. 398–408.
Martin A, James S, Arthur C. 1983. Dasar-Dasar Kimia Fisik dalam Ilmu Farmasetik. Terjemahan: Joshita, UI Press, Jakarta.
Mathews VV, Binu P, Paul MVS, Abhilash M., Manju AR.Harikumaran. 2012. Hepatoprotective efficacy of curcumin against arsenic trioxide toxicity. India. Dalam: Asian Pacific Journal of Tropical Biomedicine. Hlm. 706-711.

Mohanraj VJ, Chen Y. 2006. Nanoparticles – A Review. Dalam: Tropical Journal of Pharmaceutical Research. Hlm. 561-573
Ratnasari D, Effionora A. 2016. Karakterisasi nanovesikel transfersom sebagai pembawa rutin dalam pengembangan sediaan transdermal. Dalam: Jurnal Farmamedika. Hlm. 12-18
Rechtman MM, Bar-Yishay I, Fishman S, Adamovich Y, Shaul Y, Halpern Z, Shlomai A. 2010. Curcumin inhibits hepatitis B via down-regulation of the metabolic coactivator PGC-1α. Dalam: FEBS letters. Hlm. 2485-2486
Rianti PV. 2015. Pengaruh variasi konsentrasi surfaktan pada ukuran partikel dan efisiensi penjerapan niosom yang mengandung ekstrak etano 96% kulit batang nangka (Artocarpus heterophyllus). Skripsi. FKIK. Universitas Islam Negeri Syarif Hidayatullah, Jakarta.
Rowe, Paul J, Sian C. 2006. Handbook of Pharmaceutical Exipients Fifth Edition. American Pharmacists Assosiation. Washington. Hlm 385-386, 549-550, 675-676.
Sailaja KA, Sashikala P.2014. An overall review on liposomal drug delivery system. Dalam: Indian Journal of Novel Drug Delivery. Hlm. 112-113
Shaji J, Sharvari G. 2014. Devlopment and Characterization of Keterolac Tromethamine: A Comparative Assessment. Dalam: International Journal of Current Pharmaceutical Research Vol. 6. Hlm 88-93.
Shoaib MH, Tazeen J, Merchant HA, Yousuf RI. 1994. HPMC-Matrices for Controlled Drug Delivery: A New Model Combining Diffusion, Swelling, and Dissolution Mechanisms and Predicting the Release Kinetics. Dalam: AAPS Pharmacy Life Sciences. Hlm. 1748-56.
Siepmann J, Peppas NA. 2001, Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Dalam: Advanced Drug Delivery Review. Hlm. 139 – 157.
Song CK, Prabagar B, Chang KS, Suk JC, Saeho C, Dae DK. 2011. A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: Characterization and in vitro/in vivo evaluation. Dalam: Colloids and Surfaces B: Biointerfaces. Hlm 299– 304.
citation:   Anwar, Amalia dan Yudi, Srifiana dan Anisa Amalia, Anisa  (2022) Pengaruh Penggunaan Kombinasi Tween 60 Dan Span 60 Terhadap Laju Difusi Transethosome Kurkumin.  Bachelor thesis, Universitas Muhammadiyah Dr Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/13861/1/FFS_FARMASI_S03-190073_AMALIA%20ANWAR.pdf