eprintid: 13348 rev_number: 8 eprint_status: archive userid: 2319 dir: disk0/00/01/33/48 datestamp: 2022-10-09 06:55:31 lastmod: 2022-10-09 06:55:31 status_changed: 2022-10-09 06:55:31 type: thesis metadata_visibility: show creators_name: Lestari, Sri creators_name: Numlil Khaira Rusdi, Numlil creators_name: Nurhasnah, Nurhasnah creators_orcid: 0000-0002-9233-1557 creators_orcid: 0000-0002-9233-1557 creators_orcid: 0000-0002-9233-1557 title: Ketepatan Dosis Warfarin Pada Pasien Fibrilasi Atrium Di Poliklinik Rsjpd Harapan Kita Periode Mei 2016. ispublished: pub subjects: RS divisions: 48201 abstract: Warfarin adalah antikoagulan oral yang paling banyak digunakan untuk pencegahan tromboemboli yang disebabkan karena fibrilasi atrium (FA). Pemberian dosis warfarin secara pasti sulit untuk dilakukan,karena warfarin mempunyai indeks terapi yang sempit dan efek samping perdarahan. Penelitian ini bertujuan untuk mengevaluasi penggunaan warfarin pada pasien FA di Poliklinik RSJPD Harapan Kita berdasarkan ketepatan dosis dengan nilai INR (Internasional Normalized Ratio). Penelitian ini dilakukan dengan metode deskriptif secara retrospektif, diperoleh sampel 208 dari total sampling. Hasil penelitian menunjukkan tepat dosis warfarin sebanyak 72,12%. Terjadi 250 kejadian interaksi dari 913 obat yang digunakan dengan 4 kategori yaitu kategori A 4%, B 36,80%, kategori C 38% dan D 21,20% berdasarkan aplikasi Lexi.com. Dari hasil penelitian tentang ketepatan dosis dan interaksi obat warfarin pada pasien FA di poliklinik RSJPD Harapan Kita, masih terjadi ketidaktepatan dosis maka perlu dibuat buku panduan dosis warfarin sebagai acuan dalam menentukan dosis. Kata kunci : Fibrilasi Atrium, Warfarin, INR. date: 2022-02-25 date_type: completed full_text_status: restricted institution: Univerisitas Muhammadiyah Dr Hamka department: Fakultas Farmasi Dan Sains thesis_type: bachelor thesis_name: bphil referencetext: Agustini TT dkk. 2016. Perbandingan Dosis Warfarin terhadap Durasi Tercapainya Target INR pada Pasien CHF dengan Fibrilasi Atrial (Comparison between Warfarin Dose and Duration of Achieving Target INR in CHF Patients with Atrial Fibrillation). Jurnal Sains Farmasi & Klinis. Vol 2. Hlm 162-170. Altmann DR dkk. 2010. Use of the CHADS2 risk score to guide antithrombotic treatment in patients with atrial fibrillation-room for improvement. Department of Cardiology, University of Basel Hospital. Vol 140 (5-6). Switzerland. Hlm 73-77. Anderson dkk. 2007. Randomized trial of genotype-Guide Versus Standard Warfarin Dosing in Patient Initiating Oral Anticoagulation. Vol 116. Pubmed. Hlm 2563-2570 Anderson dkk. 2008. 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Bachelor thesis, Univerisitas Muhammadiyah Dr Hamka. document_url: http://repository.uhamka.ac.id/id/eprint/13348/1/FFS_FARMASI_S03-170254_SRI%20LESTARI.pdf