eprintid: 13224
rev_number: 8
eprint_status: archive
userid: 2319
dir: disk0/00/01/32/24
datestamp: 2022-10-09 06:47:24
lastmod: 2022-10-09 06:47:24
status_changed: 2022-10-09 06:47:24
type: thesis
metadata_visibility: show
creators_name: Pratiwi Kurnia, Arsy
creators_name: Priyo Wahyudi, Priyo
creators_name: Vera, Ladeska
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
creators_orcid: 0000-0002-9233-1557
title: Perbandingan Ekstrak Daun Pacar Kuku(Lawsonia Inermis L.) Dan Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis L.) Untuk Meningkatkan Aktivitas Enzim Tirosinase Pada Proses Melanogenesis Secara In Vitro
ispublished: pub
subjects: RS
divisions: 48201
abstract: Tirosinase merupakan enzim kunci dalam sintesis melanin. Melanin adalah
pigmen yang memiliki struktur beragam, hasil dari oksidasi dan polimerisasi
tirosin pada hewan, atau senyawa fenolik pada organisme. Senyawa fenolik
memiliki pengaruh besar terhadap peningkatan enzim tirosinase pada proses
melanogenesis. Penelitian ini bertujuan untuk mengetahui perbandingan
peningkatan aktivitas enzim tirosinase terhadap ekstrak etanol bunga kembang
sepatu (Hibiscus rosa-sinensis L.) dan daun pacar kuku (Lawsonia inermis L.).
Senyawa pada ekstrak etanol daun pacar kuku dan bunga kembang sepatu diduga
memiliki aktivitas peningkatan terhadap enzim tirosinase adalah flavonoid dan
skopoletin. Pengujian dilakukan dengan L-DOPA sebagai substrat, ekstrak etanol
daun pacar kuku dan bunga kembang sepatu dengan konsentrasi uji 10-100.000
μg/ml serta kontrol positif (8-MOP) menggunakan microplate reader pada
panjang gelombang 450 nm. Hasil penelitian menunjukkan bahwa ekstrak etanol
daun pacar kuku memiliki potensi peningkatan 0,84 kali dari 8-metoksipsoralen
lebih tinggi dibandingkan potensi peningkatan yang dihasilkan oleh bunga
kembang sepatu 0,76 kali dari 8-metoksipsoralen.

Kata Kunci: aktivator tirosinase, daun pacar kuku dan bunga kembang sepatu,
8-MOP
date: 2022-02-21
date_type: completed
full_text_status: restricted
institution: Univerisitas Muhammadiyah Dr Hamka
department: Fakultas Farmasi Dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Pratiwi Kurnia, Arsy dan Priyo Wahyudi, Priyo dan Vera, Ladeska  (2022) Perbandingan Ekstrak Daun Pacar Kuku(Lawsonia Inermis L.) Dan Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis L.) Untuk Meningkatkan Aktivitas Enzim Tirosinase Pada Proses Melanogenesis Secara In Vitro.  Bachelor thesis, Univerisitas Muhammadiyah Dr Hamka.   
document_url: http://repository.uhamka.ac.id/id/eprint/13224/1/FFS_FARMASI_S03-170359_ARSY%20KURNIA%20PRATIWI.pdf