?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Frepository.uhamka.ac.id%2Fid%2Feprint%2F1297%2F&rft.title=Peer+Review+Partition+Coefficient+and+Glutathione+Penetration+of+Topical+Antiaging%3A+Preformulation+Study&rft.creator=Fitria+Nugrahaeni%2C+Fitria&rft.subject=H+Social+Sciences&rft.description=Glutathione+(GSH)+is+a+broad+antioxidant+of+the+thiol-tripeptide+group%2C+highly+hydrophilic%2C+which+has+limitation+for+topical+preparations.+A+lipophilic+surfactant+is+an+alternative+method+to+enhance+the+glutathione+partition.+The+purpose+of+this+study+was+to+determine+the+apparent+partition+coefficient+(APC+log)+of+glutathione%3B+glutathione+with+additional+surfactant+at+different+HLB+value+of+HLB+4.3%3B+5.5%3B+7%3B+11+and+selected+HLB+was+studied+for+penetration.+The+study+was+conducted+by+dissolving+glutathione+in+water+plus+various+HLB+surfactants.+Determination+method+of+partition+coefficient+was+done+by+shake+flash+method.+The+penetration+test+was+conducted+using+the+parameter+of+decreasing+Matrix+Metalloproteinase-1+expression+on+the+balb-c+male+skin.+The+results+can+be+used+as+a+reference+for+topical+glutathione+formulations+as+these+results+are+preformulation+study.&rft.publisher=Interntional+Journal+of+Drug+Delivery+Technology&rft.type=Other&rft.type=NonPeerReviewed&rft.format=text&rft.language=en&rft.identifier=http%3A%2F%2Frepository.uhamka.ac.id%2Fid%2Feprint%2F1297%2F1%2Fpeer%2520reviwe%2520jurnal%2520kedua.pdf&rft.identifier=++Fitria+Nugrahaeni%2C+Fitria+++Peer+Review+Partition+Coefficient+and+Glutathione+Penetration+of+Topical+Antiaging%3A+Preformulation+Study.++Interntional+Journal+of+Drug+Delivery+Technology.+++++