eprintid: 12813
rev_number: 11
eprint_status: archive
userid: 2310
dir: disk0/00/01/28/13
datestamp: 2022-02-10 10:42:42
lastmod: 2022-07-18 03:49:42
status_changed: 2022-07-18 03:49:42
type: thesis
metadata_visibility: show
creators_name: Karinah, Mutia
creators_name: Hariyanti, Hariyanti
creators_name: Rachmania, Rizky Arcinthya
creators_id: hariyanti@uhamka.ac.id
creators_orcid: 0000-0001-7236-563X
title: Molecular Docking Kandungan Senyawa Biji Pepaya (Carica Papaya L.) Terhadap Enzim Hmg-Coa Reductase
Sebagai Antihiperkolesterolemia
ispublished: pub
subjects: RS
divisions: 48201
abstract: Biji pepaya (Carica papaya L.) memiliki beberapa kandungan senyawa yang diduga memiliki efek penurunan kadar kolesterol dengan mekanisme sebagai penghambat enzim HMG-CoA reductase. Penelitian ini bertujuan untuk mengetahui senyawa terbaik manakah dari biji pepaya yang memiliki interaksi dan afinitas terbaik terhadap enzim HMG-CoA reductase. Mekanisme interaksi molekul antara ligan-reseptor dapat dilakukan melalui metode molecular docking dengan software PLANTS. Ligan ditambatkan pada reseptor HMG-CoA reductase. Analisa interaksi ikatan hidrogen dilakukan melalui metode visualisasi menggunakan software Molegro Molecular Viewer (MMV). Adapun ligan dari kandungan senyawa pada biji pepaya yaitu, karpain, benzil isothiosinat, benzil glukosinolat, glukotropeolin, benzil tiourea, asam oleat, dan β-sitosterol. Hasil interaksi ligan-reseptor pada senyawa kandungan biji pepaya (Carica papaya L.) terhadap reseptor HMG-CoA reductase, diperoleh satu senyawa terbaik, yaitu benzil glukosinolat yang memiliki ChemPLP score sebesar -90,5491 kkal/mol serta memiliki sebanyak delapan interaksi ikatan hidrogen dan berpotensi untuk dapat dikembangkan sebagai kandidat obat antihiperkolesterolemia.
date: 2018
date_type: completed
full_text_status: restricted
institution: Universitas Muhammadiyah Prof. DR. HAMKA
department: Fakultas Farmasi dan Sains
thesis_type: bachelor
thesis_name: bphil
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citation:   Karinah, Mutia dan Hariyanti, Hariyanti dan Rachmania, Rizky Arcinthya  (2018) Molecular Docking Kandungan Senyawa Biji Pepaya (Carica Papaya L.) Terhadap Enzim Hmg-Coa Reductase Sebagai Antihiperkolesterolemia.  Bachelor thesis, Universitas Muhammadiyah Prof. DR. HAMKA.   
document_url: http://repository.uhamka.ac.id/id/eprint/12813/1/FFS_FARMASI_S03-190300_MUTIA%20KARINAH.pdf