TY  - JOUR
PB  - The Japan Society of Histochemistry and Cytochemistry
ID  - repository1189
UR  - http://repository.uhamka.ac.id/id/eprint/1189/
A1  - Morio Azuma, Morio Azuma
A1  - Takehiro Tsukada, Takehiro Tsukada
A1  - Takeshi Inagaki, Takeshi Inagaki
A1  - Fujianti Casmad, Fujianti
A1  - Depicha Jindatip, Depicha Jindatip
A1  - Alimuddin Tofrizal, Alimuddin
A1  - Rita Maliza, Rita Maliza
A1  - Khongorzul Batchuluun, Khongorzul Batchuluun
A1  - Rahimi Syaidah, Rahimi Syaidah
A1  - Nobuhiko Ohno, Nobuhiko Ohno
A1  - Ken Fujiwara, Ken Fujiwara
A1  - Motoshi Kikuchi, Motoshi Kikuchi
A1  - Takashi Yashiro, Yashiro
TI  - Immunohistochemical Study of the Laminin ?5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands
N2  - Laminin, a major basement membrane protein, comprises three subunit chains: ?, ?, and ?
chains. Among these chains, only the laminin ? chain is capable of signaling via laminin
receptors. Although laminin isoforms containing the ?5 chain were reported to be the first
laminin produced during rat anterior pituitary gland development, the functions of these
isoforms are unknown. We used immunohistochemical techniques to localize the laminin ?5
chain and its specific receptor, basal cell adhesion molecule (BCAM), in fetal and adult
pituitary gland. Laminin ?5 chain immunoreactivity was observed in the basement
membrane of the primordial adenohypophysis at embryonic days 12.5 to 19.5. Double
immunostaining showed that BCAM was present and co-localized with the laminin ?5 chain
in the tissue. Quantitative analysis showed that the laminin ?5 chain and BCAM were
expressed in the anterior pituitary gland during postnatal development and in adulthood
(postnatal day 60). In the adult gland, co-localization of the laminin ?5 chain and BCAM was
observed, and BCAM was detected in both the folliculo-stellate cells and endothelial cells.
These results suggest that laminin ?5 chain signaling via BCAM occurs in both the fetal
adenohypophysis and adult anterior pituitary gland.
JF  - Immunohistochemical Study of the Laminin ?5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands
AV  - public
ER  -