%0 Journal Article
%A Morio Azuma, Morio Azuma
%A Takehiro Tsukada, Takehiro Tsukada
%A Takeshi Inagaki, Takeshi Inagaki
%A Fujianti Casmad, Fujianti
%A Depicha Jindatip, Depicha Jindatip
%A Alimuddin Tofrizal, Alimuddin
%A Rita Maliza, Rita Maliza
%A Khongorzul Batchuluun, Khongorzul Batchuluun
%A Rahimi Syaidah, Rahimi Syaidah
%A Nobuhiko Ohno, Nobuhiko Ohno
%A Ken Fujiwara, Ken Fujiwara
%A Motoshi Kikuchi, Motoshi Kikuchi
%A Takashi Yashiro, Yashiro
%A UHAMKA,
%F repository:1189
%I The Japan Society of Histochemistry and Cytochemistry
%J Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands
%T Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands
%U http://repository.uhamka.ac.id/id/eprint/1189/
%X Laminin, a major basement membrane protein, comprises three subunit chains: α, β, and γ  chains. Among these chains, only the laminin α chain is capable of signaling via laminin  receptors. Although laminin isoforms containing the α5 chain were reported to be the first  laminin produced during rat anterior pituitary gland development, the functions of these  isoforms are unknown. We used immunohistochemical techniques to localize the laminin α5  chain and its specific receptor, basal cell adhesion molecule (BCAM), in fetal and adult  pituitary gland. Laminin α5 chain immunoreactivity was observed in the basement  membrane of the primordial adenohypophysis at embryonic days 12.5 to 19.5. Double  immunostaining showed that BCAM was present and co-localized with the laminin α5 chain  in the tissue. Quantitative analysis showed that the laminin α5 chain and BCAM were  expressed in the anterior pituitary gland during postnatal development and in adulthood  (postnatal day 60). In the adult gland, co-localization of the laminin α5 chain and BCAM was  observed, and BCAM was detected in both the folliculo-stellate cells and endothelial cells.  These results suggest that laminin α5 chain signaling via BCAM occurs in both the fetal  adenohypophysis and adult anterior pituitary gland.