relation: http://repository.uhamka.ac.id/id/eprint/1189/
title: Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands
creator: Morio Azuma, Morio Azuma
creator: Takehiro Tsukada, Takehiro Tsukada
creator: Takeshi Inagaki, Takeshi Inagaki
creator: Fujianti Casmad, Fujianti
creator: Depicha Jindatip, Depicha Jindatip
creator: Alimuddin Tofrizal, Alimuddin
creator: Rita Maliza, Rita Maliza
creator: Khongorzul Batchuluun, Khongorzul Batchuluun
creator: Rahimi Syaidah, Rahimi Syaidah
creator: Nobuhiko Ohno, Nobuhiko Ohno
creator: Ken Fujiwara, Ken Fujiwara
creator: Motoshi Kikuchi, Motoshi Kikuchi
creator: Takashi Yashiro, Yashiro
subject: H Social Sciences
description: Laminin, a major basement membrane protein, comprises three subunit chains: α, β, and γ  chains. Among these chains, only the laminin α chain is capable of signaling via laminin  receptors. Although laminin isoforms containing the α5 chain were reported to be the first  laminin produced during rat anterior pituitary gland development, the functions of these  isoforms are unknown. We used immunohistochemical techniques to localize the laminin α5  chain and its specific receptor, basal cell adhesion molecule (BCAM), in fetal and adult  pituitary gland. Laminin α5 chain immunoreactivity was observed in the basement  membrane of the primordial adenohypophysis at embryonic days 12.5 to 19.5. Double  immunostaining showed that BCAM was present and co-localized with the laminin α5 chain  in the tissue. Quantitative analysis showed that the laminin α5 chain and BCAM were  expressed in the anterior pituitary gland during postnatal development and in adulthood  (postnatal day 60). In the adult gland, co-localization of the laminin α5 chain and BCAM was  observed, and BCAM was detected in both the folliculo-stellate cells and endothelial cells.  These results suggest that laminin α5 chain signaling via BCAM occurs in both the fetal  adenohypophysis and adult anterior pituitary gland.
publisher: The Japan Society of Histochemistry and Cytochemistry
type: Article
type: PeerReviewed
format: text
language: en
identifier: http://repository.uhamka.ac.id/id/eprint/1189/1/51_18014.pdf
identifier:   Morio Azuma, Morio Azuma dan Takehiro Tsukada, Takehiro Tsukada dan Takeshi Inagaki, Takeshi Inagaki dan Fujianti Casmad, Fujianti dan Depicha Jindatip, Depicha Jindatip dan Alimuddin Tofrizal, Alimuddin dan Rita Maliza, Rita Maliza dan Khongorzul Batchuluun, Khongorzul Batchuluun dan Rahimi Syaidah, Rahimi Syaidah dan Nobuhiko Ohno, Nobuhiko Ohno dan Ken Fujiwara, Ken Fujiwara dan Motoshi Kikuchi, Motoshi Kikuchi dan Takashi Yashiro, Yashiro   Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands.  Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands.