@article{repository1189,
       publisher = {The Japan Society of Histochemistry and Cytochemistry},
           title = {Immunohistochemical Study of the Laminin {\ensuremath{\alpha}}5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands},
         journal = {Immunohistochemical Study of the Laminin {\ensuremath{\alpha}}5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands},
          author = {Morio Azuma, Morio Azuma and Takehiro Tsukada, Takehiro Tsukada and Takeshi Inagaki, Takeshi Inagaki and Fujianti Casmad, Fujianti and Depicha Jindatip, Depicha Jindatip and Alimuddin Tofrizal, Alimuddin and Rita Maliza, Rita Maliza and Khongorzul Batchuluun, Khongorzul Batchuluun and Rahimi Syaidah, Rahimi Syaidah and Nobuhiko Ohno, Nobuhiko Ohno and Ken Fujiwara, Ken Fujiwara and Motoshi Kikuchi, Motoshi Kikuchi and Takashi Yashiro, Yashiro},
        abstract = {Laminin, a major basement membrane protein, comprises three subunit chains: {\ensuremath{\alpha}}, {\ensuremath{\beta}}, and {\ensuremath{\gamma}}
chains. Among these chains, only the laminin {\ensuremath{\alpha}} chain is capable of signaling via laminin
receptors. Although laminin isoforms containing the {\ensuremath{\alpha}}5 chain were reported to be the first
laminin produced during rat anterior pituitary gland development, the functions of these
isoforms are unknown. We used immunohistochemical techniques to localize the laminin {\ensuremath{\alpha}}5
chain and its specific receptor, basal cell adhesion molecule (BCAM), in fetal and adult
pituitary gland. Laminin {\ensuremath{\alpha}}5 chain immunoreactivity was observed in the basement
membrane of the primordial adenohypophysis at embryonic days 12.5 to 19.5. Double
immunostaining showed that BCAM was present and co-localized with the laminin {\ensuremath{\alpha}}5 chain
in the tissue. Quantitative analysis showed that the laminin {\ensuremath{\alpha}}5 chain and BCAM were
expressed in the anterior pituitary gland during postnatal development and in adulthood
(postnatal day 60). In the adult gland, co-localization of the laminin {\ensuremath{\alpha}}5 chain and BCAM was
observed, and BCAM was detected in both the folliculo-stellate cells and endothelial cells.
These results suggest that laminin {\ensuremath{\alpha}}5 chain signaling via BCAM occurs in both the fetal
adenohypophysis and adult anterior pituitary gland.},
             url = {http://repository.uhamka.ac.id/id/eprint/1189/}
}