Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease

Nora Wulandari, NoradanMaifitrianti, MaifitriantidanNila Yusmiati Ningsih, Nila Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease. Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease.

[img]
Preview
Text
proceedings-icprp-uii-2018-halaman-148-152.pdf

Download (230kB) | Preview

Abstract

Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients with various complications that cause polypharmacy which can increase the risk of drug-drug interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse events in geriatric patients with CKD. This was a descriptive study where the samples were collected retrospectively from medical record of the patients admitted in one tertiary care hospital in Jakarta. Potential drug interaction was screened electronically using a drug interaction checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60% with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion, The prevalence of DDIs in geriatric patients with CKD was found high and major level of significance adverse event hyperkalemia was found caused by the DDIs.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Depositing User: Furqon furqon furqon
Date Deposited: 04 Feb 2020 09:15
Last Modified: 04 Feb 2020 09:15
URI: http://repository.uhamka.ac.id/id/eprint/870

Actions (login required)

View Item View Item