Nora Wulandari, Nora dan Maifitrianti, Maifitrianti dan Nila Yusmiati Ningsih, Nila Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease. Potential Drug-Drug Interaction and Actual Adverse Event in Hospitalized Geriatric Patients with Chronic Kidney Disease.
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Abstract
Chronic kidney disease (CKD) in Indonesia often occurs in elderly (geriatric) patients
with various complications that cause polypharmacy which can increase the risk of drug-drug
interactions (DDIs). This study aimed to determine the incidence of DDIs and actual adverse
events in geriatric patients with CKD. This was a descriptive study where the samples were
collected retrospectively from medical record of the patients admitted in one tertiary care hospital
in Jakarta. Potential drug interaction was screened electronically using a drug interaction
checker (drugs.com) and manually by Drug Interaction Fact 2014. A total of 699 potential DDIs
were detected from 135 patients from one-year study period. The incidence of DDIs was 92.60%
with 5.01% actual adverse event detected due to DDIs. Pharmacodynamic interactions
accounted for 46.64% with the most significant level at a moderate level (59.37%). In conclusion,
The prevalence of DDIs in geriatric patients with CKD was found high and major level of
significance adverse event hyperkalemia was found caused by the DDIs.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Depositing User: | Furqon FFS |
| Date Deposited: | 04 Feb 2020 09:15 |
| Last Modified: | 04 Feb 2020 09:15 |
| URI: | http://repository.uhamka.ac.id/id/eprint/870 |
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