Steamed Watermelon (Citrullus lanatus Thunb.) Juice Improves Spatial Memory in Dementia Rat Model

Maifitrianti, MaifitriantidanHadi Sunaryo, HadidanDedi Suryadi, Dedi Steamed Watermelon (Citrullus lanatus Thunb.) Juice Improves Spatial Memory in Dementia Rat Model. Steamed Watermelon (Citrullus lanatus Thunb.) Juice Improves Spatial Memory in Dementia Rat Model.

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Abstract

Watermelon (Citrullus lanatus Thunb.) is one of the fruits that containing lycopene. Lycopene is able to reduce oxidative damage that causes dementia. This research was aimed to determine the activity of steamed watermelon juice in improving the spatial memory in dementia rats model induced by Electroconvulsive Shock (ECS). The animal test was divided into 6 groups, namely normal control group, negative control group, positive control group (vitamin E, 20.7 mg/kg BW), and 3 treatment groups that received steamed watermelon juice with different dose, i.e 0.92 g/kg BW,1.85 g/kg BW, and 3.7 g/kg BW. All groups were induced with ECS, except for the normal control group. The spatial memory was measured with the Radial Arm Maze (RAM) test and the observed results were analyzed with ANOVA and a post-hoc Tukey’s HSD test. The ANOVA test results showed significant differences between all treatment groups. Meanwhile, the posthoc Tukey’s HSD test at 95% confidence level resulted in a significant difference between the the treatment groups with the doses of 0.92 g/kg BW and 1.85 g/kg BW and the negative control group. However, this test indicated an insignificant difference between the positive control group and the normal control group. This finding confirms that the administration of steamed watermelon juice at doses of 0.92 g/kg BW and 1.85 g/kg BW improves the spatial memory in a rat mode of dementia comparable to the positive control. The treatment groups receiving these two doses showed corresponding results, meaning that both doses of steamed watermelon juice have an equivalent spatial memory enhancement activity.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 27 Jan 2020 08:23
Last Modified: 27 Jan 2020 08:23
URI: http://repository.uhamka.ac.id/id/eprint/852

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