The Effect of Concentration Ratio of Gelatine and Polyvinylpyrrolidone as Binders on the Physical Properties of Red Ginger (Zingiber officinale Rosc.) Extract Lozenges

Inding, GusmayadidanPriyanto, Priyanto The Effect of Concentration Ratio of Gelatine and Polyvinylpyrrolidone as Binders on the Physical Properties of Red Ginger (Zingiber officinale Rosc.) Extract Lozenges. The Effect of Concentration Ratio of Gelatine and Polyvinylpyrrolidone as Binders on the Physical Properties of Red Ginger (Zingiber officinale Rosc.) Extract Lozenges.

[img]
Preview
Text
MICH-PhD_2018_26.pdf

Download (253kB) | Preview

Abstract

Lozenges require the tablet hardness of 7-14 Kgf to be a suitable binder. Gelatine can be used to meet the requirement as it creates granules with bad flow time. PVP produces granules with better flow time but it takes a large quantity to reach the lozenges hardness desired. This study aimed to determine the effect of the concentration ratio of gelatine and PVP as binders on the physical properties of red-ginger extract lozenges. Lozenges made employing the wet granulation method following the ratio of gelatine and PVP of 1:1, 1:2, 1:3, 1:4 and 1:5. The hardness test results of the formula 1 to 5 are 9, 14, 16, 13 and 12 Kgf respectively and the friability test results were 0,4%, 0,7%, 0,2%, 0,3% and 0,6% accordingly. The combination of gelatine and PVP as binders provide a significant difference in the hardness and friability of the tablets.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 19 Dec 2019 05:50
Last Modified: 19 Dec 2019 05:50
URI: http://repository.uhamka.ac.id/id/eprint/816

Actions (login required)

View Item View Item