Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan(Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters

Elly Wardani, EllydanDwitiyanti, DwitiyantidanSediarso, SediarsodanDwina Puspandiyah, Dwina Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan(Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters. Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan (Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters.

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Abstract

Diabetes mellitus is a disease characterized by hyperglycemia as well as progressive changes to the pancreatic beta cell structure. This study was conducted to determine the antihyperglycemic activity of ceplukan herb extract (Physalis angulata L.) in alloxan-induced male Syrian hamsters and high cholesterol feed. The study used 24 hamsters divided into six groups. Group I were given a standard diet and regular drinking water, Group II were given metformin dose 61,66 mg/kg body weight (BW), Group III were alloxan-induced and high cholesterol feed, Groups IV, V and VI were given extract dose 60, 120 and 240 mg/kg BW respectively. The animals were induced alloxan monohydrate as well as were given high cholesterol feed during treatment. Blood sampling was performed on the 29th and 44th day using a clinical spectrophotometer. The results show significant differences between treatment groups (α <0,05), followed by Tukey test. In conclusion, the preparation of herbal extract test ceplukan at doses of 120 and 240 mg/kg BW could reduce blood glucose levels by 50.84% and 43.41% which is equivalent to metformin dose of 61.66 mg/kg BW with a percentage of 53.12%.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 19 Dec 2019 05:50
Last Modified: 19 Dec 2019 05:50
URI: http://repository.uhamka.ac.id/id/eprint/815

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