Low-Intensity Exercise Improves Neuroplasticity and Spatial Memory on Young Adult of Male Wistar Rats

N. T. Kartinah, KartinahdanAbdullah Faizah, AbdullahdanAguspadita Diah Ayu, DiahdanTahyatul Bariroh, Tahyatul Low-Intensity Exercise Improves Neuroplasticity and Spatial Memory on Young Adult of Male Wistar Rats. Low-Intensity Exercise Improves Neuroplasticity and Spatial Memory on Young Adult of Male Wistar Rats.

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Abstract

Kartinah NT, Faizah A, Ayu AD, Tahyatu B. Low-Intensity Exercise Improves Neuroplasticity and Spatial Memory on Young Adult of Male Wistar Rats. JEPonline 2018;21(5):19-28. The purpose of this study was to examine the effect of low-intensity exercise on neuroplasticity and memory performance in young Wistar adult rats. Neuroplasticity was determined by altering the expression of proteins such as synaptophysin, neuroligin-1, AMPAR, NMDAR, and PSD-95 in the rat hippocampus. Six-month-old rats were randomly divided into Sedentary (Sed) and Exercise (Ex) Groups. Exercise rats had better spatial memory compared to sedentary rats. This result was shown by a reduction in both the time travelled and the total error in the Water-E Maze task (P<0.05). Immunohistochemistry staining showed that exercise rats had higher optical density scores of both pre- and postsynaptic proteins compared to sedentary rats (P<0.05). In conclusion, the findings indicate that the low-intensity exercise improves spatial learning and memory, as shown by increased neuroplasticity and synaptic maturation in young Wistar adult rats.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 19 Dec 2019 05:50
Last Modified: 19 Dec 2019 05:50
URI: http://repository.uhamka.ac.id/id/eprint/811

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