N. T. Kartinah, Kartinah dan Abdullah Faizah, Abdullah dan Aguspadita Diah Ayu, Diah dan Tahyatul Bariroh, Tahyatul Low-Intensity Exercise Improves Neuroplasticity and Spatial Memory on Young Adult of Male Wistar Rats. Low-Intensity Exercise Improves Neuroplasticity and Spatial Memory on Young Adult of Male Wistar Rats.
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Abstract
Kartinah NT, Faizah A, Ayu AD, Tahyatu B. Low-Intensity Exercise
Improves Neuroplasticity and Spatial Memory on Young Adult of
Male Wistar Rats. JEPonline 2018;21(5):19-28. The purpose of this
study was to examine the effect of low-intensity exercise on
neuroplasticity and memory performance in young Wistar adult rats.
Neuroplasticity was determined by altering the expression of
proteins such as synaptophysin, neuroligin-1, AMPAR, NMDAR, and
PSD-95 in the rat hippocampus. Six-month-old rats were randomly
divided into Sedentary (Sed) and Exercise (Ex) Groups. Exercise
rats had better spatial memory compared to sedentary rats. This
result was shown by a reduction in both the time travelled and the
total error in the Water-E Maze task (P<0.05). Immunohistochemistry
staining showed that exercise rats had higher optical density scores
of both pre- and postsynaptic proteins compared to sedentary rats
(P<0.05). In conclusion, the findings indicate that the low-intensity
exercise improves spatial learning and memory, as shown by
increased neuroplasticity and synaptic maturation in young Wistar
adult rats.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Keguruan & Ilmu Pendidikan > Pendidikan Ekonomi |
| Depositing User: | Furqon FFS |
| Date Deposited: | 19 Dec 2019 05:50 |
| Last Modified: | 19 Dec 2019 05:50 |
| URI: | http://repository.uhamka.ac.id/id/eprint/811 |
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