VARIATION CONCENTRATION OF CITRIC ACID AS ACID SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP MANGOSTEEN (Garcinia mangostana L) EXTRACT EFFERVESCENT TABLET

Inding, GusmayadidanPramulani Mulya, LestaridanErike Trisnande, Erike VARIATION CONCENTRATION OF CITRIC ACID AS ACID SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP MANGOSTEEN (Garcinia mangostana L) EXTRACT EFFERVESCENT TABLET. VARIATION CONCENTRATION OF CITRIC ACID AS ACID SOURCES ON THE PHYSICAL PROPERTIES OF THE PERICARP MANGOSTEEN (Garcinia mangostana L) EXTRACT EFFERVESCENT TABLET.

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Abstract

Citric acid is an acid source in effervescent tablet it reacts rapidly, can increase dissolving time. In this research, extract was made into effervescent tablet. The research aimed at knowing increased concentration of citric acid as acid source can improve the physical characteristic of effervescent tablet. Pericarp mangosteen dry extracts macerated by water, and powder made by spray dryer. Dry extract was made into 5 formulas effervescent tablet with the different concentrations of citric acid, 15%, 20%, 25%, 30% and 35% as acid sources. The tablets were evaluated included organoleptic evaluation, weight uniformity, size uniformity, hardness, friability, and dissolving times. The result of dissolving time are 10,50±0,57 minutes, 4,52±1,04 minutes, 3,32±0,13 minutes, 3,13±0,14 minutes and 3,42±0,14 minutes. By one way ANOVA test dissolving time data showed differences each other 95% in signifigancies. It can be concluded that increasing of citric acid gave effect on dissolving time, and the citric acid with concentration of 35% can reduce dissolving time of the pericarp mangosteen (Garcinia mangostana L.) dry extract effervescent tablets.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 19 Dec 2019 05:50
Last Modified: 19 Dec 2019 05:50
URI: http://repository.uhamka.ac.id/id/eprint/805

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