THE EFFECT OF β-LACTAM ADMINISTRATION ON NEW INFECTION BY ESBL PRODUCTION BACTERIA AT PERSAHABATAN HOSPITAL

Numlil, Khaira Rusdi THE EFFECT OF β-LACTAM ADMINISTRATION ON NEW INFECTION BY ESBL PRODUCTION BACTERIA AT PERSAHABATAN HOSPITAL. Faculty of Pharmacy and Sciences Muhammadiyah Prof.DR. HAMKA University, Jakarta Timur. ISBN 978-602-71959-0-5 (In Press)

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Abstract

The excessive administration of antibiotics betalactame. especially third generation cephalosporin widely for the treatment of infections in hospital was thought to be one factor contributing to infection by bacteria Extented-Spectrum-Betalactamase (ESBL). In hospital Persahabatan known that many third-generation cephalosporin antibiotic used for the treatment of hospitalized patients. This study aimed to determine the effect of beta-lactam antibiotics against infection by the emergence of ESBL-producing bacteria at Persahabatan hospital Jakarta period January to March. 2013. This study was case control study.involving patients with ESBL positive as case group and ESBL negative as control group. Historical use of antibiotics during hospitalization in Persahabatan traced in medical records retrospectively. Data were analyzed using chisquare test or fisher exact test followed by odd ratio calculation and calculate the DDD (Defined Daily Dose) to determine the quantity administration of antibiotic betalactame. A total of 100 patients.50 patients are included into the case group and 50 into the control group. Bivariate analysis showed that a history of antibiotic Betalactame use in general (p = 0.357) was not a factor influencing the emergence of infections by ESBLproducing bacteria. Historical administration of ceftriaxone (third-generation cephalosporin) (p = 0.016. OR = 2.705. 95% CI = 1.197 to 6.113) were factors that influence the emergence of infections by ESBL producing bacteria.

Item Type: Book
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: admin repository uhamka
Date Deposited: 03 Oct 2016 05:58
Last Modified: 03 Oct 2016 05:58
URI: http://repository.uhamka.ac.id/id/eprint/80

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