Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate

Lusi, Putri DwitadanVivi Anggia, VividanTri Dewi Prasetyatuti, Tri Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate. Artocarpus altilis Leaves Activity in Inhibiting α-Amylase Enzyme as Oral Antidiabetic Drug Candidate.

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Abstract

Background: The search for effective antidiabetic drugs remains to be a focus of research in the world. Artocarpus have been used as traditional medicine in South-East Asia. One of the species, Artocarpus altilis has been known in Indonesia as traditional treatment for diabetic. Objective: This research aimed to discover α-amylase inhibitor activity of Artocarpus altilis leaves. Methods: Leaves were extracted by maceration method, followed by phytochemical screening and quercetin identification using LC-MS method. Inhibition of α-amylase was measured using UV-Vis spectrophotometer at 524 nm wavelength, while antioxidant activity was determined using DPPH. Results: Artocarpus altilis leaves ethanol extract exhibited activity against α-amylase with 155.96 ppm IC50 (0.27 times relative potential compared to acarbose) and the extract showed antioxidant activity with the IC50 of 999.96 ppm. Conclusion: Artocarpus altilis showed activity as the α-amylase inhibitor.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 19 Dec 2019 05:49
Last Modified: 19 Dec 2019 05:49
URI: http://repository.uhamka.ac.id/id/eprint/787

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