Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters

Dwitiyanti, DwitiyantidanNi Putu Ermi Hikmawati, ErmidanKriana, EfendidanRiana Puspa Dewi, RianadanFernita Afriyani, Fernita Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters. Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters.

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Abstract

In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has been used for various health condition. This study aims to determine the effectiveness of 70% ethanol extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves were extracted using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4 hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol, LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70% ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded that the 70% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in hyperlipidemic hamster equivalent to positive control group.

Item Type: Article
Subjects: Fakultas Agama Islam > R Medicine (General)
Fakultas Agama Islam > RS Pharmacy and materia medica
Divisions: Fakultas Keguruan & Ilmu Pendidikan > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 18 Dec 2019 04:57
Last Modified: 18 Dec 2019 04:57
URI: http://repository.uhamka.ac.id/id/eprint/751

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