Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion

Rahmah, Elfiyani and Yudi, Srifiana and Nauval Audia, Andamdewi Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion. Comparison of Carbopol 934 and 941 as Thickener on Diffusion Rate of Ketoconazole Microemulsion. ISSN 0975-1459

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Abstract

Aim: This study aimed to compare the diffusion rate of ketoconazole in microemulsion containing carbopol 934 or carbopol 941 as a thickener. Methods: Ketoconazole microemulsion was made into 7 formulas with various concentrations in each type of thickener, i.e 0.1%, 0.2%, 0.3%, and one formula without thickener. Each formula were evaluated includes organoleptic, pH measurement, viscosity, particle size, potential zeta, surface tension measurement, and diffusion test. Results: The physical properties of ketoconazole microemulsion showed liquid to gel form, yellow in color, specific odor, pH was in the range of 7.00-7.65, viscosity ranged from 2196-26037 cps, particle size was 13.6-42.2nm, zeta potential was -9.12--18.44 mV, and surface tension 30.7-64 dyne / cm. The diffusion kinetics obtained followed by the higuchi equation for the use of the two thickener, while the ketoconazole microemulsion without thickener (F1) followed the Korsmeyer-peppas equation with a diffusion rate of 9.444 %/minute. The diffusion rate of ketoconazole microemulsion with carbopol 934 (F2, F3, F4) were 4.354, 4.638, and 4.847 %/minute, respectively. Meanwhile, the diffusion rate using carbopol 941 (F5, F6, F7) were 4.695, 4.742, 4.751 %/minute, respectively. Conclusion: It can be concluded that the diffusion rate (sig ˂ 0,05,) of ketoconazole in microemulsion containing carbopol 941 was faster than diffusion rate of microemulsion containing carbopol 934 at the same concentration in the microemulsion system.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 21 Feb 2019 01:29
Last Modified: 21 Feb 2019 01:29
URI: http://repository.uhamka.ac.id/id/eprint/638

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