FORMULASI MUKOADHESIF NIFEDIPIN MENGGUNAKAN KOMBINASI POLIMER CARBOPOL 943 DAN GELATIN TYPE B

Ari, Widayanti and Hauzal, Halim and Muslim, Suardi FORMULASI MUKOADHESIF NIFEDIPIN MENGGUNAKAN KOMBINASI POLIMER CARBOPOL 943 DAN GELATIN TYPE B. FORMULASI MUKOADHESIF NIFEDIPIN MENGGUNAKAN KOMBINASI POLIMER CARBOPOL 943 DAN GELATIN TYPE B.

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Abstract

Mucoadhesive strength test ofpolimer exipient is important for development of oral sustained re/ease with mucoadhesive system to increase bioavailability. Mucoadhesive strength ofniphedipine granule which is prepared by using combination of polymers gelatin and carbopol 934 on rat stomach and intestine had been determined by bioadhesion and wash off test. In this research the various effect of gelatin concentrationson the mucoadhesive strength was determined. Mucoadhesive strength test was conducted with gelatin 2%, 3%, 4%, 5% and as a controll carbopol 934 was used. The study started with the evaluation of characteristics of niphedipine particles with ball mill s/ze. Evaluation of characteristics of the test were wit/? DCS, IR, X-Ray, SEM and then was followed by the preparation ofgranule mucoadhesive niphedipine. t/3e evaluation were granules, bioadhesive test, wash off test and dissolution test. Result showed that F 4 with 5% gelatin could be adhesive to rat stomach and intestine in 5 minutes. The strongest adhesion to stomach and intestine were the granule combination of gelatin 5°Z and carbopol 934 5% with the amount of granule adhesive to stomach and intestine were 94,67% and 98%.Results indicated that the dissolution profit of all the formula did not follow either zero order, first order. The result showed that released of niphedipine from all formulation has followed Higuchi kinetics.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 04 Feb 2019 02:41
Last Modified: 04 Feb 2019 02:41
URI: http://repository.uhamka.ac.id/id/eprint/629

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