Effects of Sonicator Usage Time on Entrapment Efficiency of Liposome Magnesium Ascorbyl Phosphate Made by Thin Layer Hydration Method.

Ari, Widayanti and Rahma, Elfiyani and Thiara Eka, Febriyani Effects of Sonicator Usage Time on Entrapment Efficiency of Liposome Magnesium Ascorbyl Phosphate Made by Thin Layer Hydration Method. Effects of Sonicator Usage Time on Entrapment Efficiency of Liposome Magnesium Ascorbyl Phosphate Made by Thin Layer Hydration Method.. ISSN 0975-8585

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Abstract

Magnesium Ascorbyl Phosphate (MAP) is one of derivatives of vitamin C which is more stable in water. MAP hydrophilic nature makes it difficult to penetrate the stratum corneum. Therefore, to increase the penetration, MAP is encapsulated in a liposome system. The sonication can be used to regulated the vesicles size and increase the entrapment efficiency. The purpose of this research was to investigate the effects of sonicator usage time on entrapment efficiency. The thin layer hydration method was used to prepare MAP liposomes with a ratio of lecithin and cholesterol in 30: 1, respectively. The variations of sonicator usage time were 10,15 and 20 minutes. Characterization of liposomes was observed by morphology, vesicle size and drug entrapment studies. The results showed that MAP entrapment efficiency percentage consecutively was 63.4705%; 70.4261%; and 78.0869%; while the size obtained is 466.9 nm; 298.6 nm; and 179.4 nm. One-way ANOVA test results showed a significant difference in each treatment. It can be concluded that the increasing sonicator usage time can decrease vesicle size and increase entrapment efficiency of MAP liposomes. Keywords: Liposomes, Magnesium Ascorbyl Phosphate, Sonication, Sonicator

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 04 Feb 2019 02:42
Last Modified: 04 Feb 2019 02:42
URI: http://repository.uhamka.ac.id/id/eprint/621

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