COMPARISON OF SODIUM LAURYL SULPHATE, SODIUM BENZOATE, POLYAETHYLENE GLYCOLUM 6000 AS LUBRICANT ON DISSOLVING TIME OF EXTRACT CIPLUKAN (Physalis angulata L.) EFFERVESCENT TABLET

Ari, Widayanti and Hadi Sunaryo, Hadi and Nurita, Sari COMPARISON OF SODIUM LAURYL SULPHATE, SODIUM BENZOATE, POLYAETHYLENE GLYCOLUM 6000 AS LUBRICANT ON DISSOLVING TIME OF EXTRACT CIPLUKAN (Physalis angulata L.) EFFERVESCENT TABLET. COMPARISON OF SODIUM LAURYL SULPHATE, SODIUM BENZOATE, POLYAETHYLENE GLYCOLUM 6000 AS LUBRICANT ON DISSOLVING TIME OF EXTRACT CIPLUKAN (Physalis angulata L.) EFFERVESCENT TABLET. ISSN 978-602-71959-0-5

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Abstract

Ciplukan is a plant that widely used as a traditional medicine e.g : anti-inflammatory, bronchitis, ulcers, cancer, tumors, leukemia and diabetes mellitus due to chemical compounds like saponin , terpenoids, and alkaloids. This research was conducted by making extract ciplukan effervescent tablet using sodium lauryl sulfat, PEG 6000 and sodium benzoate as lubricant. This tablet was made in 3 formula i.e 2% of sodium lauryl sulfat (F1), 3% of PEG 6000 (F2) and 4% of sodium benzoate. The tablet was evaluated for weight uniformity, size uniformity, hardness, friability, dissolve time, and pH’s test. The result shows that the comparison of lubricant can give different in dissolving time. Formula II shows the dissolving time quicker than formula I and formula III. By one way ANOVA analyses with 95% of significance level , among all combinations showed a significant differences.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: Furqon furqon furqon
Date Deposited: 04 Feb 2019 02:42
Last Modified: 04 Feb 2019 02:42
URI: http://repository.uhamka.ac.id/id/eprint/620

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